Single‐cell transcriptome analysis reveals that maternal obesity affects DNA repair, histone methylation, and autophagy level in mouse embryos
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30201
Abstract: Obesity causes many reproductive dysfunctions such as reduced conception, infertility, and early pregnancy loss, and this is largely due to the negative effects of obesity on oocyte and embryo quality. In the present study, we… read more here.
Keywords: single cell; analysis; level; histone methylation ... See more keywords
Novel combination of histone methylation modulators with therapeutic synergy against acute myeloid leukemia in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.10.015
Abstract: Acute myeloid leukemia (AML) is a hematological malignancy with rapid disease progression and often becomes lethal without treatment. Development of effective new therapies is essential to improve the clinical outcome of AML patients. Enhancer of… read more here.
Keywords: combination; myeloid leukemia; histone methylation; acute myeloid ... See more keywords
Histone methylation-associated transgenerational inheritance of reproductive defects in Caenorhabditis elegans exposed to crude oil under various exposure scenarios.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.02.080
Abstract: As part of a study to explore the long-term effects of the Hebei Spirit oil spill accident, transgenerational toxicity and associated epigenetic changes were investigated in the nematode Caenorhabditis elegans. Under experimental conditions, worms were… read more here.
Keywords: methylation; exposure; caenorhabditis elegans; histone methylation ... See more keywords
Involvement of histone methylation in macrophage apoptosis and unstable plaque formation in methionine‐induced hyperhomocysteinemic ApoE−/− mice
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.02.003
Abstract: Aims: Hyperhomocysteinemia (Hhcy) is an independent risk factor of atherosclerosis and promotes unstable plaque formation. Epigenetic mechanisms play an important role in the pathogenesis of atherosclerosis induced by Hhcy. However, the exact mechanism is still… read more here.
Keywords: apoptosis; formation; unstable plaque; histone methylation ... See more keywords
Noncoding RNAs involved in DNA Methylation and Histone methylation, and acetylation in Diabetic Vascular Complications.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105520
Abstract: Diabetes is a metabolic disorder and its incidence is still increasing. Diabetic vascular complications cause major diabetic mobility and include accelerated atherosclerosis, nephropathy, retinopathy, and neuropathy. Hyperglycemia contributes to the pathogenesis of diabetic vascular complications… read more here.
Keywords: methylation; diabetic vascular; histone methylation; vascular complications ... See more keywords
Controlling the Controllers: Regulation of Histone Methylation by Phosphosignalling.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2020.08.004
Abstract: Histone methylation is central to the regulation of eukaryotic transcription. Here, we review how the histone methylation system itself is regulated. There is substantial evidence that mammalian histone methyltransferases and demethylases are phosphorylated and regulated… read more here.
Keywords: controlling controllers; methylation; controllers regulation; regulation histone ... See more keywords
DNA and Histone Methylation Regulates Different Types of Fruit Ripening by Transcriptome and Proteome Analyses.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c06391
Abstract: Methylation affects different aspects of genetic material stability, gene expression regulation, and histone modification. The previous reports depicted that DNA and histone methylation regulates plant growth and development. In this study, we evaluated the effects… read more here.
Keywords: methylation; fruit ripening; expression; histone methylation ... See more keywords
Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-62593-9
Abstract: The process of implantation, trophoblast invasion and placentation demand continuous adaptation and modifications between the trophoblast (embryonic) and the decidua (maternal). Within the decidua, the maternal immune system undergoes continued changes, as the pregnancy progress,… read more here.
Keywords: cxcl10 expression; decidua; human chorionic; histone methylation ... See more keywords
Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117209119
Abstract: Significance In this study, we identify microRNA-32-5p (miR-32-5p) as a key functional noncoding RNA in trigeminal-mediated neuropathic pain. We report that injury-induced histone methylation attenuates the binding of glucocorticoid receptor to the promoter region of… read more here.
Keywords: histone methylation; cav3 channels; neuropathic pain; regulation ... See more keywords
Genetic variants in the histone methylation and acetylation pathway and their risks in eight types of cancers
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Digestive Diseases"
DOI: 10.1111/1751-2980.12574
Abstract: The histone methylation and acetylation pathway genes regulate cell growth and survival. Aberrations in this pathway are implicated in a variety of cancers. This study aimed to identify germline genetic variants in histone methylation and… read more here.
Keywords: histone methylation; methylation acetylation; types cancers; acetylation pathway ... See more keywords
Disorders of histone methylation: Molecular basis and clinical syndromes
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Genetics"
DOI: 10.1111/cge.14181
Abstract: Epigenetic modifications of DNA and histone tails are essential for gene expression regulation. They play an essential role in neurodevelopment as nervous system development is a complex process requiring a dynamic pattern of gene expression.… read more here.
Keywords: methylation; histone methylation; clinical syndromes; disorders histone ... See more keywords