Expression and clinical significance of COMPASS family of histone methyltransferases in clear cell renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.06.063
Abstract: The regulation of histone 3 lysine 4 (H3K4) methylation code is indispensable for the cell as any disturbance in this has been associated with many pathologic conditions, like cancer. The SET domain-containing lysine methyltransferase 2… read more here.
Keywords: family histone; kmt2 family; histone methyltransferases; cell ... See more keywords
Exploring Methods of Targeting Histone Methyltransferases and Their Applications in Cancer Therapeutics.
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DOI: 10.1021/acschembio.2c00062
Abstract: Histone methyltransferases (HMTs) are enzymes that catalyze the methylation of lysine or arginine residues of histone proteins, a key post-translational modification (PTM). Aberrant expression or activity of these enzymes can lead to abnormal histone methylation… read more here.
Keywords: exploring methods; histone methyltransferases; histone; methods targeting ... See more keywords
Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens
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DOI: 10.1128/mbio.01141-17
Abstract: ABSTRACT Epigenetic regulation is based on a network of complexes that modulate the chromatin character and structure of the genome to impact gene expression, cell fate, and development. Thus, epigenetic modulators represent novel therapeutic targets… read more here.
Keywords: viral pathogens; suppress infection; infection; methyltransferases ezh2 ... See more keywords
Abstract 4756: NSD1/2 histone methyltransferases regulate cell growth in HPV-negative head and neck squamous cell carcinoma (HNSCC)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4756
Abstract: Members of the NSD protein family (NSD1, NSD2, and NSD3) are histone methyltransferases (HMTs) that catalyze lysine 36 dimethylation (K36me2) at histone H3. H3K36 modifications play an important role in regulating the function and structure… read more here.
Keywords: nsd1 nsd2; cell; histone methyltransferases; hnscc ... See more keywords
Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.814216
Abstract: Perturbations to the epigenome are known drivers of tumorigenesis. In melanoma, alterations in histone methyltransferases that catalyze methylation at histone 3 lysine 9 and histone 3 lysine 27—two sites of critical post-translational modification—have been reported.… read more here.
Keywords: methyltransferases alter; histone methyltransferases; alter melanoma; histone lysine ... See more keywords
Histone Methyltransferases as Therapeutic Targets for Kidney Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.01393
Abstract: Emerging evidence has demonstrated that epigenetic regulation plays a vital role in gene expression under normal and pathological conditions. Alterations in the expression and activation of histone methyltransferases (HMTs) have been reported in preclinical models… read more here.
Keywords: kidney diseases; histone methyltransferases; therapeutic targets; methyltransferases therapeutic ... See more keywords
The SUV4-20H Histone Methyltransferases in Health and Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094736
Abstract: The post-translational modification of histone tails is a dynamic process that provides chromatin with high plasticity. Histone modifications occur through the recruitment of nonhistone proteins to chromatin and have the potential to influence fundamental biological… read more here.
Keywords: suv4 20h; histone methyltransferases; histone; methyltransferases health ... See more keywords