Novel histone modifications in microglia derived from a mouse model of chronic pain
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202100137
Abstract: As the resident immune cells in the central nervous system, microglia play an important role in the maintenance of its homeostasis. Dysregulation of microglia has been associated with the development and maintenance of chronic pain.… read more here.
Keywords: histone modifications; modifications microglia; development; chronic pain ... See more keywords
Cracking chromatin with proteomics: From chromatome to histone modifications
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202100206
Abstract: Chromatin is the assembly of genomic DNA and proteins packaged in the nucleus of eukaryotic cells, which together are crucial in regulating a plethora of cellular processes. Histones may be the best known class of… read more here.
Keywords: histone modifications; chromatin proteomics; chromatin; cracking chromatin ... See more keywords
Measuring Histone Modifications in the Human Parasite Schistosoma mansoni.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0635-3_9
Abstract: DNA-binding proteins play critical roles in many major processes such as development and sexual biology of Schistosoma mansoni and are important for the pathogenesis of schistosomiasis. Chromatin immunoprecipitation (ChIP) experiments followed by sequencing (ChIP-seq) are… read more here.
Keywords: histone modifications; biology; schistosoma mansoni; measuring histone ... See more keywords
Chromatin Immunoprecipitation of Histone Modifications in Fission Yeast.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6630-1_12
Abstract: Chromatin immunoprecipitation (ChIP) is a sensitive, accurate, and reliable technique widely used to analyze protein-DNA interactions at specific binding sites in vivo. It has been a particularly powerful technique for mapping of histone modification patterns… read more here.
Keywords: fission yeast; histone modifications; histone; chromatin immunoprecipitation ... See more keywords
Physarum polycephalum for Studying the Function of Histone Modifications In Vivo.
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DOI: 10.1007/978-1-4939-6630-1_15
Abstract: Histone modifications have been widely correlated with genetic activities. However, how these posttranslational modifications affect the dynamics and the structure of chromatin is poorly understood. Here, we describe the incorporation of the exogenous histone proteins… read more here.
Keywords: polycephalum studying; histone modifications; histone; physarum polycephalum ... See more keywords
Characterization of expansin genes and their transcriptional regulation by histone modifications in strawberry.
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DOI: 10.1007/s00425-021-03665-6
Abstract: MAIN CONCLUSION The possible candidate expansin genes, which may be important for strawberry fruit softening, have been identified in the diploid woodland strawberry Fragaria vesca and the octoploid cultivated strawberry Fragaria × ananassa and their transcriptional regulation by… read more here.
Keywords: fruit; histone modifications; exp genes; transcriptional regulation ... See more keywords
Moving pharmacoepigenetics tools for depression toward clinical use.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2019.02.009
Abstract: BACKGROUND Major depressive disorder (MDD) is a leading cause of disability worldwide, and over half of patients do not achieve symptom remission following an initial antidepressant course. Despite evidence implicating a strong genetic basis for… read more here.
Keywords: depression; histone modifications; response; treatment ... See more keywords
Targeting post-translational histone modifications for the treatment of non-medullary thyroid cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.05.036
Abstract: Genomic and epigenetic alterations are now being exploited as molecular targets in cancer treatment. Abnormalities involving the post-translational modification of histones have been demonstrated in thyroid cancer, and they are regarded as promising molecular targets… read more here.
Keywords: histone modifications; treatment; post translational; thyroid cancer ... See more keywords
Histone modifications in epigenetic regulation of cancer: perspectives and achieved progress.
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2020.07.015
Abstract: Epigenetic changes associated with histone modifications play an important role in the emergence and maintenance of the phenotype of various cancer types. In contrast to direct mutations in the main DNA sequence, these changes are… read more here.
Keywords: histone modifications; role; cancer; histone ... See more keywords
Global analysis of histone modifications and long-range chromatin interactions revealed the differential cistrome changes and novel transcriptional players in human dilated cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.06.001
Abstract: BACKGROUND Acetylation and methylation of histones alter the chromatin structure and accessibility that affect transcriptional regulators binding to enhancers and promoters. The binding of transcriptional regulators enables the interaction between enhancers and promoters, thus affecting… read more here.
Keywords: chromatin interactions; analysis; histone modifications; heart failure ... See more keywords
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications
Sign Up to like & getrecommendations! Published in 2017 at "Nature Neuroscience"
DOI: 10.1038/s41593-017-0057-1
Abstract: Internal N6-methyladenosine (m6A) modification is widespread in messenger RNAs (mRNAs) and is catalyzed by heterodimers of methyltransferase-like protein 3 (Mettl3) and Mettl14. To understand the role of m6A in development, we deleted Mettl14 in embryonic… read more here.
Keywords: histone modifications; embryonic neural; m6a; modification ... See more keywords