The expanding landscape of ‘oncohistone’ mutations in human cancers
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1038-1
Abstract: Mutations in epigenetic pathways are common oncogenic drivers. Histones, the fundamental substrates for chromatin-modifying and remodelling enzymes, are mutated in tumours including gliomas, sarcomas, head and neck cancers, and carcinosarcomas. Classical ‘oncohistone’ mutations occur in… read more here.
Keywords: histone mutations; oncohistone mutations; mutations occur; expanding landscape ... See more keywords
Acidic patch histone mutations and their effects on nucleosome remodeling.
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DOI: 10.1042/bst20210773
Abstract: Structural and biochemical studies have identified a histone surface on each side of the nucleosome disk termed 'the nucleosome acidic patch' that acts as a regulatory hub for the function of numerous nuclear proteins, including… read more here.
Keywords: nucleosome remodeling; patch histone; histone mutations; acidic patch ... See more keywords
The mechanistic GEMMs of oncogenic histones.
Sign Up to like & getrecommendations! Published in 2020 at "Human molecular genetics"
DOI: 10.1093/hmg/ddaa143
Abstract: The last decade's progress unraveling the mutational landscape of all age groups of cancer has uncovered mutations in histones as vital contributors of tumorigenesis. Here we review three new aspects of oncogenic histones: first, the… read more here.
Keywords: histone mutations; oncogenic histones; cancer; gemms oncogenic ... See more keywords