Epiproteome profiling of cadmium‐transformed human bronchial epithelial cells by quantitative histone post‐translational modification–enzyme‐linked immunosorbent assay
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3597
Abstract: Cadmium (Cd), a carcinogenic toxic metal, is pervasively distributed in the soil, water and air. Chronic exposure to Cd has been correlated to lung disease development including cancers. Although many studies have been conducted to… read more here.
Keywords: post translational; epiproteome profiling; cadmium; histone post ... See more keywords
Histone Post-Translational Modifications and Nucleosome Organisation in Transcriptional Regulation: Some Open Questions.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2017_58
Abstract: The organisation of chromatin is first discussed to conclude that nucleosomes play both structural and transcription-regulatory roles. The presence of nucleosomes makes difficult the access of transcriptional factors to their target sequences and the action… read more here.
Keywords: organisation; modifications nucleosome; post translational; open questions ... See more keywords
Native Chromatin Proteomics (N-ChroP) to Characterize Histone Post-translational Modification (PTM) Combinatorics at Distinct Genomic Regions.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1597-3_14
Abstract: In this chapter, we describe the proteomic approach named "Native Chromatin Proteomics" (N-ChroP) that couples a modified Chromatin ImmunoPrecipitation (ChIP) protocol with the mass spectrometry (MS) analysis of immunoprecipitated proteins to study the combinatorial enrichment… read more here.
Keywords: post translational; chromatin proteomics; proteomics chrop; histone post ... See more keywords
Histone post-translational modifications as potential therapeutic targets for pain management.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2021.08.002
Abstract: Effective pharmacological management of pain associated with tissue pathology is an unmet medical need. Transcriptional modifications in nociceptive pathways are pivotal for the development and the maintenance of pain associated with tissue damage. Accumulating evidence… read more here.
Keywords: post translational; management; histone post; translational modifications ... See more keywords
A practical guide for analysis of histone post-translational modifications by mass spectrometry: best practices and pitfalls.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.12.001
Abstract: Advances in mass spectrometry (MS) have revolutionized the ability to measure global changes in histone post-translational modifications (PTMs). The method routinely quantifies over 60 modification states in a single sample, far exceeding the capabilities of… read more here.
Keywords: mass spectrometry; analysis; post translational; histone post ... See more keywords
Distinct Histone Post-translational Modifications during Plasmodium falciparum Gametocyte Development.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00108
Abstract: Histones are the building units of nucleosomes, which constitute chromatin. Histone post-translational modifications (PTMs) play an essential role in epigenetic gene regulation. The Plasmodium falciparum genome encodes canonical and variant histones and a collection of… read more here.
Keywords: plasmodium falciparum; translational modifications; histone; post translational ... See more keywords
Intracellular Formation of a DNA Damage-Induced, Histone Post-Translational Modification Following Bleomycin Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c02880
Abstract: Evaluating the significance of various forms of DNA damage is complicated by discoveries that some lesions inactivate repair enzymes or produce more deleterious forms of damage. Histone lysines within nucleosomes react with the commonly produced… read more here.
Keywords: modification; damage; dna damage; histone post ... See more keywords
Spatial epi-proteomics enabled by histone post-translational modification analysis from low-abundance clinical samples
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Epigenetics"
DOI: 10.1186/s13148-021-01120-7
Abstract: Background Increasing evidence linking epigenetic mechanisms and different diseases, including cancer, has prompted in the last 15 years the investigation of histone post-translational modifications (PTMs) in clinical samples. Methods allowing the isolation of histones from patient… read more here.
Keywords: post translational; epi proteomics; spatial epi; histone post ... See more keywords
The Use of Mononucleosome Immunoprecipitation for Analysis of Combinatorial Histone Post-translational Modifications and Purification of Nucleosome-Interacting Proteins
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00331
Abstract: The nucleosome is the principal structural unit of chromatin. Although many studies focus on individual histone post-translational modifications (PTMs) in isolation, it is important to recognize that multiple histone PTMs can function together or cross-regulate… read more here.
Keywords: post translational; use mononucleosome; histone post; translational modifications ... See more keywords
Role of Histone Post-Translational Modifications in Inflammatory Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.852272
Abstract: Inflammation is a defensive reaction for external stimuli to the human body and generally accompanied by immune responses, which is associated with multiple diseases such as atherosclerosis, type 2 diabetes, Alzheimer’s disease, psoriasis, asthma, chronic… read more here.
Keywords: histone modifications; histone; role; histone post ... See more keywords
The Expanding Constellation of Histone Post-Translational Modifications in the Epigenetic Landscape
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12101596
Abstract: The emergence of a nucleosome-based chromatin structure accompanied the evolutionary transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the complex and precisely timed coordination between chromatin architecture and functions during… read more here.
Keywords: post translational; expanding constellation; histone post; post ... See more keywords