Adverse effects of leptin on histone‐to‐protamine transition during spermatogenesis are prevented by melatonin in Sprague‐Dawley rats
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DOI: 10.1111/and.12814
Abstract: This study examines the effect of melatonin on leptin‐induced changes in transition of histone to protamine in adult rats during spermatogenesis. Twelve‐week‐old Sprague‐Dawley rats were randomised into control, leptin‐, leptin–melatonin‐10‐, leptin–melatonin‐20‐ and melatonin‐10‐treated groups with… read more here.
Keywords: histone protamine; leptin; protamine transition; melatonin ... See more keywords
Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced in vitro fertilization
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DOI: 10.3389/fendo.2022.1099270
Abstract: Introduction Oligoasthenoteratozoospermia (OAT) is a major cause of infertility in males. Only a few pathogenic genes of OAT have been clearly identified till now. A large number of OAT-affected cases remain largely unknown. Methods Here,… read more here.
Keywords: protamine exchange; oligoasthenoteratozoospermia; fertilization; histone protamine ... See more keywords
The Art of Packaging the Sperm Genome: Molecular and Structural Basis of the Histone-To-Protamine Exchange
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.895502
Abstract: Male fertility throughout life hinges on the successful production of motile sperm, a developmental process that involves three coordinated transitions: mitosis, meiosis, and spermiogenesis. Germ cells undergo both mitosis and meiosis to generate haploid round… read more here.
Keywords: basis histone; exchange; protamine exchange; histone protamine ... See more keywords