Histone modification signatures in human sperm distinguish clinical abnormalities
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-018-1354-7
Abstract: PurposeAlternations to the paternal epigenome, specifically the components of sperm chromatin, can lead to infertility in humans and potentially transmit aberrant information to the embryo. One key component of sperm chromatin is the post-translational modification… read more here.
Keywords: histone ptms; sperm; modification; motility ... See more keywords
Integrative Chemical Biology Approaches to Deciphering the Histone Code: A Problem-Driven Journey.
Sign Up to like & getrecommendations! Published in 2021 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00463
Abstract: ConspectusThe hereditary blueprint of a eukaryotic cell is encoded in its genomic DNA that is tightly compacted into chromatin together with histone proteins. The basic repeating units of chromatin fibers are nucleosomes, in which approximately… read more here.
Keywords: histone ptms; histone code; histone; biology ... See more keywords