Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and Its Histone H3 Tail Binding.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.01.015
Abstract: Importin4 transports histone H3/H4 in complex with Asf1a to the nucleus for chromatin assembly. Importin4 recognizes the nuclear localization sequence located at the N-terminal tail of histones. Here, we analyzed the structures and interactions of… read more here.
Keywords: histone tail; human importin4; importin4; asf1a ... See more keywords
Cystatin B-deficiency triggers ectopic histone H3 tail cleavage during neurogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105418
Abstract: Cystatin B (CSTB) acts as an inhibitor of cysteine proteases of the cathepsin family and loss-of-function mutations result in human brain diseases with a genotype-phenotype correlation. In the most severe case, CSTB-deficiency disrupts brain development,… read more here.
Keywords: histone tail; cleavage; cystatin; tail cleavage ... See more keywords
Probing the Protein-Protein Interaction between the ATRXADD Domain and the Histone H3 Tail
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25071500
Abstract: While loss-of-function mutations in the ATRX gene have been implicated as a driving force for a variety of pediatric brain tumors, as well as pancreatic neuroendocrine tumors, the role of ATRX in gene regulation and… read more here.
Keywords: protein; protein interaction; histone tail; protein protein ... See more keywords