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   Articles with "histone variant" as a keyword



Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.

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recommendations! Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2016.12.065

Abstract: Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene… read more here.

Keywords: h3t; testis specific; h3t gene; variant h3t ... See more keywords
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Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms14995

Abstract: The senescence of mammalian cells is characterized by a proliferative arrest in response to stress and the expression of an inflammatory phenotype. Here we show that histone H2A.J, a poorly studied H2A variant found only… read more here.

Keywords: variant h2a; senescent cells; h2a; expression ... See more keywords

The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-09899-z

Abstract: The Tip60/p400 chromatin-modifying complex, which is involved in the incorporation and post-translational modification of the H2A.Z histone variant, regulates cell proliferation and important signaling pathways, such as Wnt. Here, we study the involvement of H2A.Z… read more here.

Keywords: homeostasis; intestinal epithelial; histone variant; h2a ... See more keywords

Histone variant macroH2A: from chromatin deposition to molecular function.

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recommendations! Published in 2019 at "Essays in biochemistry"

DOI: 10.1042/ebc20180062

Abstract: The eukaryotic genome is regulated in the context of chromatin. Specialized histones, known as histone variants, incorporate into chromatin to replace their canonical counterparts and represent an important layer of regulation to diversify the structural… read more here.

Keywords: chromatin; chromatin deposition; histone variant; histone ... See more keywords

H2A.Z-nucleosomes are stabilized by the superhelicity-dependent DNA binding of the C-terminal tail of the histone variant

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recommendations! Published in 2025 at "Nucleus"

DOI: 10.1080/19491034.2025.2557113

Abstract: ABSTRACT Using an in situ nucleosome stability assay based on salt extraction, we identified distinct stability features of H2A.Z-containing nucleosomes linked to alternative interactions of the histone variant’s C-terminal tail (Imre et al., Nat. Commun.,… read more here.

Keywords: stability; tail; histone variant; topology ... See more keywords
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Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells

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recommendations! Published in 2020 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaa360

Abstract: Abstract Nucleosome is the basic structural unit of chromatin, and its dynamics plays critical roles in the regulation of genome functions. However, how the nucleosome structure is regulated by histone variants in vivo is still… read more here.

Keywords: variant h2a; h2a nucleosomes; ctcf binding; h2a ... See more keywords

Structural basis of chromatin regulation by histone variant H2A.Z.

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recommendations! Published in 2021 at "Nucleic acids research"

DOI: 10.1093/nar/gkab907

Abstract: The importance of histone variant H2A.Z in transcription regulation has been well established, yet its mechanism-of-action remains enigmatic. Conflicting evidence exists in support of both an activating and a repressive role of H2A.Z in transcription.… read more here.

Keywords: variant h2a; chromatin regulation; h2a; histone variant ... See more keywords

Dual role of histone variant H3.3B in spermatogenesis: positive regulation of piRNA transcription and implication in X-chromosome inactivation

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac541

Abstract: Abstract The histone variant H3.3 is encoded by two distinct genes, H3f3a and H3f3b, exhibiting identical amino-acid sequence. H3.3 is required for spermatogenesis, but the molecular mechanism of its spermatogenic function remains obscure. Here, we… read more here.

Keywords: spermatogenesis; role; pirna; regulation ... See more keywords

H2B.W2, a spermatocyte-specific histone variant, disrupts nucleosome stability, and reduces chromatin compaction

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf825

Abstract: Abstract Spermatogenesis is a highly regulated process that requires precise chromatin remodeling, which includes the incorporation of testis-specific histone variants. While several of these variants have been characterized, the role of H2B.W2, a member of… read more here.

Keywords: histone; h2b; spermatocyte specific; histone variant ... See more keywords

Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs.

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recommendations! Published in 2022 at "Stem cells"

DOI: 10.1093/stmcls/sxab004

Abstract: DNA damage repair (DDR) is a safeguard for genome integrity maintenance. Increasing DDR efficiency could increase the yield of induced pluripotent stem cells (iPSC) upon reprogramming from somatic cells. The epigenetic mechanisms governing DDR during… read more here.

Keywords: variant macroh2a1; macroh2a1; repair; macroh2a1 macroh2a1 ... See more keywords

Pol II kicks out histone variant

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recommendations! Published in 2020 at "Science"

DOI: 10.1126/science.368.6498.1444-b

Abstract: Gene Regulation When we think of histone proteins, we generally think of H2A, H2B, H3, and H4 because they are the histones that package DNA within our cells. However, other histone variants perform important regulatory… read more here.

Keywords: pol kicks; pol; kicks histone; histone variant ... See more keywords