Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2016.12.065
Abstract: Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene… read more here.
Keywords: h3t; testis specific; h3t gene; variant h3t ... See more keywords
Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14995
Abstract: The senescence of mammalian cells is characterized by a proliferative arrest in response to stress and the expression of an inflammatory phenotype. Here we show that histone H2A.J, a poorly studied H2A variant found only… read more here.
Keywords: variant h2a; senescent cells; h2a; expression ... See more keywords
The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09899-z
Abstract: The Tip60/p400 chromatin-modifying complex, which is involved in the incorporation and post-translational modification of the H2A.Z histone variant, regulates cell proliferation and important signaling pathways, such as Wnt. Here, we study the involvement of H2A.Z… read more here.
Keywords: homeostasis; intestinal epithelial; histone variant; h2a ... See more keywords
Histone variant macroH2A: from chromatin deposition to molecular function.
Sign Up to like & getrecommendations! Published in 2019 at "Essays in biochemistry"
DOI: 10.1042/ebc20180062
Abstract: The eukaryotic genome is regulated in the context of chromatin. Specialized histones, known as histone variants, incorporate into chromatin to replace their canonical counterparts and represent an important layer of regulation to diversify the structural… read more here.
Keywords: chromatin; chromatin deposition; histone variant; histone ... See more keywords
Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa360
Abstract: Abstract Nucleosome is the basic structural unit of chromatin, and its dynamics plays critical roles in the regulation of genome functions. However, how the nucleosome structure is regulated by histone variants in vivo is still… read more here.
Keywords: variant h2a; h2a nucleosomes; ctcf binding; h2a ... See more keywords
Structural basis of chromatin regulation by histone variant H2A.Z.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab907
Abstract: The importance of histone variant H2A.Z in transcription regulation has been well established, yet its mechanism-of-action remains enigmatic. Conflicting evidence exists in support of both an activating and a repressive role of H2A.Z in transcription.… read more here.
Keywords: variant h2a; chromatin regulation; h2a; histone variant ... See more keywords
Dual role of histone variant H3.3B in spermatogenesis: positive regulation of piRNA transcription and implication in X-chromosome inactivation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac541
Abstract: Abstract The histone variant H3.3 is encoded by two distinct genes, H3f3a and H3f3b, exhibiting identical amino-acid sequence. H3.3 is required for spermatogenesis, but the molecular mechanism of its spermatogenic function remains obscure. Here, we… read more here.
Keywords: spermatogenesis; role; pirna; regulation ... See more keywords
Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxab004
Abstract: DNA damage repair (DDR) is a safeguard for genome integrity maintenance. Increasing DDR efficiency could increase the yield of induced pluripotent stem cells (iPSC) upon reprogramming from somatic cells. The epigenetic mechanisms governing DDR during… read more here.
Keywords: variant macroh2a1; macroh2a1; repair; macroh2a1 macroh2a1 ... See more keywords
Pol II kicks out histone variant
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.368.6498.1444-b
Abstract: Gene Regulation When we think of histone proteins, we generally think of H2A, H2B, H3, and H4 because they are the histones that package DNA within our cells. However, other histone variants perform important regulatory… read more here.
Keywords: pol kicks; pol; kicks histone; histone variant ... See more keywords
The Histone Variant H2A.Z C-Terminal Domain Has Locus-Specific Differential Effects on H2A.Z Occupancy and Nucleosome Localization
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02550-22
Abstract: We provide evidence that the Saccharomyces cerevisiae C-terminal region of histone variant H2A.Z can mediate its special function in performing gene regulation by interacting with effector proteins and chaperones. These functional interactions allow H2A.Z not… read more here.
Keywords: terminal region; region; h2a; variant h2a ... See more keywords
The histone variant macroH2A1.1 regulates RNA polymerase II-paused genes within defined chromatin interaction landscapes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.259456
Abstract: ABSTRACT The histone variant macroH2A1.1 plays a role in cancer development and metastasis. To determine the underlying molecular mechanisms, we mapped the genome-wide localization of endogenous macroH2A1.1 in the human breast cancer cell line MDA-MB-231.… read more here.
Keywords: variant macroh2a1; paused genes; macroh2a1; rna polymerase ... See more keywords