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   Articles with "histone variants" as a keyword



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Studying the Evolution of Histone Variants Using Phylogeny.

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recommendations! Published in 2018 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-8663-7_15

Abstract: Histones wrap DNA to form nucleosomes that package eukaryotic genomes. Histone variants have evolved for diverse functions including gene expression, DNA repair, epigenetic silencing, and chromosome segregation. With the rapid increase of newly sequenced genomes… read more here.

Keywords: evolution histone; histone variants; variants using; using phylogeny ... See more keywords

The Role of Histone Variants in Cancer

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recommendations! Published in 2019 at "Clinical Epigenetics"

DOI: 10.1007/978-981-13-8958-0_6

Abstract: In eukaryotes, chromosomal DNA is packaged around histone proteins into tightly coiled structures, called nucleosomes, which then form further repeating condensed elements. This fundamental repeating unit, chromatin, ensures that the large eukaryotic genome can pack… read more here.

Keywords: histone variants; chromatin; gene expression; structure ... See more keywords

DNA methylation and histone variants in aging and cancer.

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recommendations! Published in 2021 at "International review of cell and molecular biology"

DOI: 10.1016/bs.ircmb.2021.06.002

Abstract: Aging-related diseases such as cancer can be traced to the accumulation of molecular disorder including increased DNA mutations and epigenetic drift. We provide a comprehensive review of recent results in mice and humans on modifications… read more here.

Keywords: variants aging; histone variants; cancer; methylation histone ... See more keywords

Effective binding of copper(II) with the peptide acetyl-GYDVEK-amide, model of the globular domain N-terminal of somatic histone H1 variants

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recommendations! Published in 2017 at "Inorganica Chimica Acta"

DOI: 10.1016/j.ica.2017.04.025

Abstract: Abstract The interaction of Cu(II) ions with the peptide Ac-GYDVEK-amide (N and C-terminal protected), a well conserved sequence located at N-terminal of the globular domain of somatic histone H1 variants (H1.1–H1.5) was studied by means… read more here.

Keywords: histone variants; globular domain; domain; gydvek amide ... See more keywords

Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes

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recommendations! Published in 2025 at "Biochemical Journal"

DOI: 10.1042/bcj20240543

Abstract: Histones play a fundamental role in eukaryotic organisms not only as scaffolding proteins in DNA packaging but also in regulating gene expression. They constitute the protein reel around which DNA wraps forming nucleosomes. This initial… read more here.

Keywords: building blocks; histone variants; epigenetic code; histones building ... See more keywords
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Elucidating the influence of linker histone variants on chromatosome dynamics and energetics

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recommendations! Published in 2020 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaa121

Abstract: Abstract Linker histones are epigenetic regulators that bind to nucleosomes and alter chromatin structures and dynamics. Biophysical studies have revealed two binding modes in the linker histone/nucleosome complex, the chromatosome, where the linker histone is… read more here.

Keywords: histone variants; linker; linker histone; elucidating influence ... See more keywords

Genomic profiling of six human somatic histone H1 variants denotes that H1X accumulates at recently incorporated transposable elements

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recommendations! Published in 2024 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae014

Abstract: Abstract Histone H1, a vital component in chromatin structure, binds to linker DNA and regulates nuclear processes. We have investigated the distribution of histone H1 variants in a breast cancer cell line using ChIP-Seq. Two… read more here.

Keywords: profiling six; histone variants; genomic profiling; recently incorporated ... See more keywords

Functional Impact of MacroH2A Histone Variants in Acute Myeloid Leukemia

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-122099

Abstract: Histone variants are emerging as key regulatory molecules in cancer. Recent data provided first evidence of how transcriptional deregulation and changes in the deposition of histone variants may affect malignant transformation. H2A variants are highly… read more here.

Keywords: functional impact; histone variants; macroh2a; h2afy ... See more keywords

Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells

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recommendations! Published in 2018 at "BMC Biology"

DOI: 10.1186/s12915-018-0568-6

Abstract: BackgroundThe hierarchical organization of eukaryotic chromatin plays a central role in gene regulation, by controlling the extent to which the transcription machinery can access DNA. The histone variants H3.3 and H2A.Z have recently been identified… read more here.

Keywords: histone variants; mes cells; prc2 dependent; gene expression ... See more keywords

Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure

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recommendations! Published in 2017 at "Clinical Epigenetics"

DOI: 10.1186/s13148-017-0416-5

Abstract: BackgroundAlcohol consumption during pregnancy is a significant public health problem and can result in a continuum of adverse outcomes to the fetus known as fetal alcohol spectrum disorders (FASD). Subjects with FASD show significant neurological… read more here.

Keywords: alcohol exposure; turnover; brain; histone variants ... See more keywords

MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms

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recommendations! Published in 2018 at "EMBO reports"

DOI: 10.15252/embr.201744445

Abstract: MacroH2A histone variants suppress tumor progression and act as epigenetic barriers to induced pluripotency. How they impart their influence on chromatin plasticity is not well understood. Here, we analyze how the different domains of macroH2A… read more here.

Keywords: distinct mechanisms; histone variants; chromatin plasticity; two distinct ... See more keywords