Differentiation of the fungus Histoplasma capsulatum into a pathogen of phagocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2017.10.003
Abstract: Mammalian body temperature triggers differentiation of the fungal pathogen Histoplasma capsulatum into yeast cells. The Drk1 regulatory kinase and an interdependent network of Ryp transcription factors establish the yeast state. Beyond morphology, the differentiation-dependent expression… read more here.
Keywords: pathogen; differentiation fungus; differentiation; histoplasma capsulatum ... See more keywords
Molecular regulation of Histoplasma dimorphism.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2019.10.011
Abstract: Temperature serves as a fundamental signal in biological systems. In some microbial pathogens of humans, mammalian body temperature triggers establishment and maintenance of a developmental program that allows the microbe to survive and thrive in… read more here.
Keywords: molecular regulation; temperature; regulation histoplasma; histoplasma dimorphism ... See more keywords
Cross-reactivity of a Histoplasma capsulatum antigen enzyme immunoassay in urine specimens from persons with emergomycosis in South Africa.
Sign Up to like & getrecommendations! Published in 2020 at "Medical mycology"
DOI: 10.1093/mmy/myaa100
Abstract: Histoplasma antigen detection in urine is a rapid diagnostic method for disseminated histoplasmosis, although cross-reactivity has been reported in specimens from patients with other thermally dimorphic fungal infections. We tested urine specimens, from persons with… read more here.
Keywords: diagnosis; cross; urine specimens; culture ... See more keywords
Evaluation of a commercial histoplasma antigen detection enzyme immunoassays for the follow-up of histoplasmosis treatment in people living with HIV from Argentina.
Sign Up to like & getrecommendations! Published in 2024 at "Medical mycology"
DOI: 10.1093/mmy/myae121
Abstract: Histoplasmosis poses a significant risk to HIV patients, particularly in regions with limited access to antiretroviral therapy. Antigen detection assays are crucial in these settings for timely diagnosis and treatment, which can reduce mortality. While… read more here.
Keywords: histoplasma; treatment; antigen; antigen detection ... See more keywords
97. Hemophagocytic Lymphohistiocytosis in Disseminated Histoplasmosis: an Overlooked Diagnosis
Sign Up to like & getrecommendations! Published in 2025 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofae631.034
Abstract: Abstract Background Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome involving pathologic excitation of the immune system. Disseminated histoplasmosis (DH) is a known trigger of HLH. However, the prevalence of HLH in DH is not known.… read more here.
Keywords: hemophagocytic lymphohistiocytosis; histoplasma; disseminated histoplasmosis; hlh ... See more keywords
Considerations about the Geographic Distribution of Histoplasma Species
Sign Up to like & getrecommendations! Published in 2022 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.02010-21
Abstract: Histoplasmosis is a mycotic infection principally affecting pulmonary tissue; sometimes, histoplasmosis can progress into a systemic disease. This infection involves immunocompetent and immunosuppressed human and other mammalian hosts, depending on particular circumstances. ABSTRACT Histoplasmosis is… read more here.
Keywords: distribution histoplasma; histoplasma; considerations geographic; infection ... See more keywords
Histoplasma capsulatum Relies on Tryptophan Biosynthesis To Proliferate within the Macrophage Phagosome
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00059-23
Abstract: Histoplasma capsulatum yeasts reside and proliferate within the macrophage phagosome during infection. This nutrient-depleted phagosomal environment imposes challenges to Histoplasma yeasts for nutrition acquisition. Histoplasma yeasts require all 20 amino acids, which can be formed… read more here.
Keywords: within macrophage; histoplasma; biosynthesis; macrophage phagosome ... See more keywords
The Brief Case: Histoplasma duboisii—an Infection with a Rare Organism Presenting as an Abdominal Mass
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.01201-21
Abstract: CASE A34-year-old female presented at a hospital in San Antonio with worsening of chronic diffuse abdominal pain and subjective fevers. The patient presented in mild distress without a history of weight loss, loss of appetite,… read more here.
Keywords: histoplasma; histoplasma duboisii; yeast cells; microbiology ... See more keywords
Genomic epidemiology of Histoplasma in Africa
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DOI: 10.1128/mbio.00564-25
Abstract: ABSTRACT Histoplasmosis, the disease caused by thermally dimorphic fungi in the genus Histoplasma, is usually associated with pulmonary involvement in healthy individuals and a disseminated syndrome in immunocompromised patients. Among African patients, lung disease is… read more here.
Keywords: epidemiology; histoplasma; lineage; africa ... See more keywords
Chromosome-Level Genome Assembly of a Human Fungal Pathogen Reveals Synteny among Geographically Distinct Species
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DOI: 10.1128/mbio.02574-21
Abstract: Histoplasma species are dimorphic fungi causing significant morbidity and mortality worldwide. These fungi grow as mold in the soil and as budding yeast within the human host. Histoplasma can be isolated from soil in diverse… read more here.
Keywords: fungal pathogen; chromosome level; among geographically; histoplasma ... See more keywords
Mac1-Dependent Copper Sensing Promotes Histoplasma Adaptation to the Phagosome during Adaptive Immunity
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DOI: 10.1128/mbio.03773-21
Abstract: Histoplasma capsulatum is a fungal pathogen that survives and grows within host macrophages. For successful infection, Histoplasma must sense and adapt to a dynamic intracellular environment over the course of an infection. ABSTRACT Intracellular pathogens… read more here.
Keywords: low copper; immunity; copper; mac1 ... See more keywords