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   Articles with "histotripsy" as a keyword



Development of an Injectable Hydrogel for Histotripsy Ablation Toward Future Glioblastoma Therapy Applications

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recommendations! Published in 2024 at "Annals of Biomedical Engineering"

DOI: 10.1007/s10439-024-03601-1

Abstract: Glioblastoma (GBM) is the most common and malignant type of primary brain tumor. Even after surgery and chemoradiotherapy, residual GBM cells can infiltrate the healthy brain parenchyma to form secondary tumors. To mitigate GBM recurrence,… read more here.

Keywords: injectable hydrogel; gbm cells; hydrogel; glioblastoma ... See more keywords

A comparative study of histotripsy parameters for the treatment of fibrotic ex-vivo human benign prostatic hyperplasia tissue

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-71163-2

Abstract: Histotripsy is a noninvasive focused ultrasound therapy that mechanically fractionates tissue to create well-defined lesions. In a previous clinical pilot trial to treat benign prostatic hyperplasia (BPH), histotripsy did not result in consistent objective improvements… read more here.

Keywords: treatment; prostatic hyperplasia; benign prostatic; histotripsy ... See more keywords

Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound

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recommendations! Published in 2021 at "International Journal of Hyperthermia"

DOI: 10.1080/02656736.2021.1905189

Abstract: Abstract Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology guided by real-time imaging. Using focused ultrasound delivered from outside the body, histotripsy mechanically destroys tissue through cavitation, rendering the target into acellular debris.… read more here.

Keywords: first noninvasive; histotripsy first; non ionizing; noninvasive non ... See more keywords

First-in-man histotripsy of hepatic tumors: the THERESA trial, a feasibility study

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recommendations! Published in 2022 at "International Journal of Hyperthermia"

DOI: 10.1080/02656736.2022.2112309

Abstract: Abstract Rationale Current hepatic locoregional therapies are limited in terms of effectiveness and toxicities. Given promising pre-clinical results, a first in-human trial was designed to assess the technical effectiveness and safety profile of histotripsy, a… read more here.

Keywords: liver; trial; tissue destruction; histotripsy ... See more keywords

Effects of f-number on the histotripsy intrinsic threshold and cavitation bubble cloud behavior.

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recommendations! Published in 2017 at "Physics in medicine and biology"

DOI: 10.1088/1361-6560/aa54c7

Abstract: Histotripsy is an ultrasound ablation method that depends on the initiation of a cavitation bubble cloud to fractionate soft tissue. Although previous work has provided significant insight into the process of intrinsic threshold histotripsy, the… read more here.

Keywords: cavitation bubble; histotripsy; effects number; number ... See more keywords

Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.

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recommendations! Published in 2019 at "Physics in medicine and biology"

DOI: 10.1088/1361-6560/ab1a64

Abstract: Focused ultrasound therapies are a noninvasive means to ablate tissue. Histotripsy utilizes short ultrasound pulses with sufficient tension to nucleate bubble clouds that impart lethal strain to the surrounding tissues. Tracking bubble cloud dissolution between… read more here.

Keywords: plane wave; histotripsy; bubble cloud; dissolution ... See more keywords

Boiling histotripsy-induced mechanical ablation modulates tumour microenvironment by promoting immunogenic cell death of cancers

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recommendations! Published in 2019 at "Annals of Oncology"

DOI: 10.1093/annonc/mdz238.071

Abstract: Abstract Background Boiling histotripsy is a promising non-invasive High-Intensity Focused Ultrasound (HIFU) technique that employs HIFU mechanical effects to fractionate solid tumours without causing any signicant thermal damage. It has been suggested that boiling histotripsy… read more here.

Keywords: immunogenic cell; histotripsy; boiling histotripsy; cell death ... See more keywords

Histotripsy for the Treatment of Cholangiocarcinoma Liver Tumors: In Vivo Feasibility and Ex Vivo Dosimetry Study

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recommendations! Published in 2021 at "IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control"

DOI: 10.1109/tuffc.2021.3073563

Abstract: Histotripsy is a noninvasive, nonionizing, and nonthermal focused ultrasound ablation method that is currently being developed for the treatment of liver cancer. Promisingly, histotripsy has been shown for ablating primary [hepatocellular carcinoma (HCC)] and metastatic… read more here.

Keywords: treatment; tumors vivo; histotripsy; liver tumors ... See more keywords

MRI Coregistered Rodent Histotripsy Array for Orthotopic Liver Models

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recommendations! Published in 2025 at "IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control"

DOI: 10.1109/tuffc.2025.3553083

Abstract: Histotripsy has emerged as a promising therapeutic option for liver tumors, recently gaining food and drug administration (FDA) approval for clinical use in October 2023. Preclinical in vivo histotripsy experiments primarily utilize subcutaneous ectopic murine… read more here.

Keywords: mri coregistered; histotripsy array; liver; histotripsy ... See more keywords

Chirp-Coded Subharmonic Imaging With Volterra Filtering: Histotripsy Bubble Cloud Assessment In Vitro and Ex Vivo

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recommendations! Published in 2025 at "IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control"

DOI: 10.1109/tuffc.2025.3556030

Abstract: Histotripsy is a noninvasive focused ultrasound therapy that liquifies tissue via bubble activity. Conventional ultrasound imaging is used in current clinical practice to monitor histotripsy. Developing surrogate imaging metrics for successful treatment outcomes remains an… read more here.

Keywords: bubble cloud; subharmonic imaging; chirp coded; histotripsy ... See more keywords

Real-time acoustic-based feedback for histotripsy therapy

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recommendations! Published in 2017 at "Journal of the Acoustical Society of America"

DOI: 10.1121/1.4987518

Abstract: Histotripsy uses high-pressure microsecond ultrasound pulses to generate cavitation to fractionate cells in target tissues. Two acoustic-based feedback mechanisms are being investigated to monitor histotripsy therapy in real-time. First, bubble-induced color Doppler (BICD) is received… read more here.

Keywords: cavitation; real time; histotripsy; acoustic based ... See more keywords