Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2021.1905189
Abstract: Abstract Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology guided by real-time imaging. Using focused ultrasound delivered from outside the body, histotripsy mechanically destroys tissue through cavitation, rendering the target into acellular debris.… read more here.
Keywords: first noninvasive; histotripsy first; non ionizing; noninvasive non ... See more keywords
First-in-man histotripsy of hepatic tumors: the THERESA trial, a feasibility study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2022.2112309
Abstract: Abstract Rationale Current hepatic locoregional therapies are limited in terms of effectiveness and toxicities. Given promising pre-clinical results, a first in-human trial was designed to assess the technical effectiveness and safety profile of histotripsy, a… read more here.
Keywords: liver; trial; tissue destruction; histotripsy ... See more keywords
Effects of f-number on the histotripsy intrinsic threshold and cavitation bubble cloud behavior.
Sign Up to like & getrecommendations! Published in 2017 at "Physics in medicine and biology"
DOI: 10.1088/1361-6560/aa54c7
Abstract: Histotripsy is an ultrasound ablation method that depends on the initiation of a cavitation bubble cloud to fractionate soft tissue. Although previous work has provided significant insight into the process of intrinsic threshold histotripsy, the… read more here.
Keywords: cavitation bubble; histotripsy; effects number; number ... See more keywords
Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.
Sign Up to like & getrecommendations! Published in 2019 at "Physics in medicine and biology"
DOI: 10.1088/1361-6560/ab1a64
Abstract: Focused ultrasound therapies are a noninvasive means to ablate tissue. Histotripsy utilizes short ultrasound pulses with sufficient tension to nucleate bubble clouds that impart lethal strain to the surrounding tissues. Tracking bubble cloud dissolution between… read more here.
Keywords: plane wave; histotripsy; bubble cloud; dissolution ... See more keywords
Boiling histotripsy-induced mechanical ablation modulates tumour microenvironment by promoting immunogenic cell death of cancers
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz238.071
Abstract: Abstract Background Boiling histotripsy is a promising non-invasive High-Intensity Focused Ultrasound (HIFU) technique that employs HIFU mechanical effects to fractionate solid tumours without causing any signicant thermal damage. It has been suggested that boiling histotripsy… read more here.
Keywords: immunogenic cell; histotripsy; boiling histotripsy; cell death ... See more keywords
Histotripsy for the Treatment of Cholangiocarcinoma Liver Tumors: In Vivo Feasibility and Ex Vivo Dosimetry Study
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control"
DOI: 10.1109/tuffc.2021.3073563
Abstract: Histotripsy is a noninvasive, nonionizing, and nonthermal focused ultrasound ablation method that is currently being developed for the treatment of liver cancer. Promisingly, histotripsy has been shown for ablating primary [hepatocellular carcinoma (HCC)] and metastatic… read more here.
Keywords: treatment; tumors vivo; histotripsy; liver tumors ... See more keywords
Real-time acoustic-based feedback for histotripsy therapy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Acoustical Society of America"
DOI: 10.1121/1.4987518
Abstract: Histotripsy uses high-pressure microsecond ultrasound pulses to generate cavitation to fractionate cells in target tissues. Two acoustic-based feedback mechanisms are being investigated to monitor histotripsy therapy in real-time. First, bubble-induced color Doppler (BICD) is received… read more here.
Keywords: cavitation; real time; histotripsy; acoustic based ... See more keywords
Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2019-000200
Abstract: Background Developing the ability to use tumor-directed therapies to trigger potentially therapeutic immune responses against cancer antigens remains a high priority for cancer immunotherapy. We hypothesized that histotripsy, a novel non-invasive, non-thermal ablation modality that… read more here.
Keywords: immunotherapy; ablation; histotripsy; immune responses ... See more keywords
(More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0261567
Abstract: Deep vein thrombosis is a major source of morbidity and mortality worldwide. For acute proximal deep vein thrombosis, catheter-directed thrombolytic therapy is an accepted method for vessel recanalization. Thrombolytic therapy is not without risk, including… read more here.
Keywords: catheter; fibrinolysis; combined histotripsy; dose ... See more keywords
Impact of Histotripsy on Development of Intrahepatic Metastases in a Rodent Liver Tumor Model
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071612
Abstract: Simple Summary Histotripsy is a novel technique that mechanically disrupts tumors, through precisely controlled acoustic cavitation. There is insufficient evidence regarding the effects of histotripsy on the risk of recurrence and metastases, following tumor debulking.… read more here.
Keywords: survival outcomes; model; tumor; histotripsy ... See more keywords
Characterizing the Ablative Effects of Histotripsy for Osteosarcoma: In Vivo Study in Dogs
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15030741
Abstract: Simple Summary Histotripsy is a non-invasive focused ultrasound therapy, in development, for treating osteosarcoma (OS). Small pilot studies describing ex vivo and in vivo histotripsy ablation of OS have demonstrated the feasibility and safety of… read more here.
Keywords: vivo; histotripsy ablation; effects histotripsy; histotripsy ... See more keywords