Laboratory Testing Protocols for Heparin-Induced Thrombocytopenia (HIT) Testing.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7196-1_19
Abstract: Heparin-induced thrombocytopenia (HIT) represents a significant high morbidity complication of heparin therapy. The clinicopathological diagnosis of HIT remains challenging for many reasons; thus, laboratory testing represents an important component of an accurate diagnosis. Although there… read more here.
Keywords: thrombocytopenia hit; laboratory testing; induced thrombocytopenia; heparin induced ... See more keywords
The association between patient engagement HIT functionalities and quality of care: Does more mean better?
Sign Up to like & getrecommendations! Published in 2019 at "International journal of medical informatics"
DOI: 10.1016/j.ijmedinf.2019.05.029
Abstract: OBJECTIVE To explore the relationship between the number (breadth) of patient engagement functionalities offered through health information technology (HIT) by hospitals and the hospitals' quality of care. METHODS Data on hospital adoption of patient engagement… read more here.
Keywords: quality care; patient engagement; engagement; hit ... See more keywords
Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract - A Two-Hit Hypothesis.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in microbiology"
DOI: 10.1016/j.tim.2017.12.002
Abstract: Chlamydia trachomatis, a leading bacterial cause of sexually transmitted infection-induced infertility, is frequently detected in the gastrointestinal tract. Chlamydia muridarum, a model pathogen for investigating C. trachomatis pathogenesis, readily spreads from the mouse genital tract… read more here.
Keywords: gastrointestinal tract; muridarum; tract; tract gastrointestinal ... See more keywords
Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00403
Abstract: The dysregulated Hippo pathway and, consequently, hyperactivity of the transcriptional YAP/TAZ-TEAD complexes is associated with diseases such as cancer. Prevention of YAP/TAZ-TEAD triggered gene transcription is an attractive strategy for therapeutic intervention. The deeply buried… read more here.
Keywords: msc 4106; site; binding fragment; optimization ... See more keywords
Implication of mitochondrial ROS-NLRP3 inflammasome axis during two-hit mediated acute lung injury in mice
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2021.2023740
Abstract: Abstract Acute lung injury (ALI) caused by acid aspiration often accompanies bacterial components leading to exaggerated inflammation and can result in acute respiratory distress syndrome (ARDS), but the underlying mechanisms behind such an exacerbation remain… read more here.
Keywords: inflammation; two hit; hit mediated; nlrp3 inflammasome ... See more keywords
Perspectives on chemotherapy for the management of double-hit lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2020.1727445
Abstract: ABSTRACT Introduction Double-hit (DHL) and triple-hit lymphomas (THL) have long been among the most clinically aggressive molecular subtypes of diffuse large B-cell lymphomas. In the 2016 revised WHO classification, they represent a new entity called… read more here.
Keywords: lymphoma; double hit; perspectives chemotherapy; chemotherapy management ... See more keywords
Extending the Morphological Hit-or-Miss Transform to Deep Neural Networks
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Neural Networks and Learning Systems"
DOI: 10.1109/tnnls.2020.3025723
Abstract: While most deep learning architectures are built on convolution, alternative foundations such as morphology are being explored for purposes such as interpretability and its connection to the analysis and processing of geometric structures. The morphological… read more here.
Keywords: morphological hit; neural networks; hit miss; miss transform ... See more keywords
Single-hit inactivation drove tumor suppressor genes out of the X chromosome during evolution.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3458
Abstract: Cancer-related genes are under intense evolutionary pressure. In this study, we conjecture that X-linked tumor suppressor genes (TSG) are not protected by the Knudson's two-hit mechanism and are therefore subject to negative selection. Accordingly, nearly… read more here.
Keywords: suppressor genes; single hit; tumor suppressor; hit inactivation ... See more keywords
One-Hit Wonders versus Hit Makers: Sustaining Success in Creative Industries
Sign Up to like & getrecommendations! Published in 2022 at "Administrative Science Quarterly"
DOI: 10.1177/00018392221083650
Abstract: Creative industries produce many one-hit wonders who struggle to repeat their initial success and fewer hit makers who sustain success over time. To develop theory on the role of creativity in driving sustained market success,… read more here.
Keywords: creative industries; hit makers; hit wonders; success ... See more keywords
Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.952832
Abstract: Tuberous sclerosis complex (TSC) is a multisystem genetic disorder caused by pathogenic variants in TSC1 and TSC2 genes. TSC patients present with seizures and brain abnormalities such as tubers and subependymal giant cells astrocytoma (SEGA).… read more here.
Keywords: mutant zebrafish; hit; model; tsc2 ... See more keywords
TP53 /KRAS Co-Mutations Create Divergent Prognosis Signatures in Intrahepatic Cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.844800
Abstract: Background: Due to high invasiveness and heterogeneity, the morbidity and mortality of intrahepatic cholangiocarcinoma (ICC) remain unsatisfied. Recently, the exploration of genomic variants has decoded the underlying mechanisms of initiation and progression for multiple tumors,… read more here.
Keywords: intrahepatic cholangiocarcinoma; mutation; tp53 kras; prognosis ... See more keywords