Abstract C088: Intelligent Hit Discovery Platform for Accelerated Cyclic Peptide Radiopharmaceutical Development
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DOI: 10.1158/1535-7163.targ-25-c088
Abstract: We present an integrated hit discovery platform for radiopharmaceutical drug conjugates (RDCs) that synergizes high-throughput biophysical screening (SPR, MST) with phage display technology to rapidly identify and optimize high-affinity cyclic peptide binders against oncology targets.… read more here.
Keywords: methodology; discovery platform; hit discovery; cyclic peptide ... See more keywords
Abstract A013: Facilitating AI-Based Hit Discovery through the Development of the AIRCHECK Platform
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.aimachine-a013
Abstract: Efficient hit discovery is a critical step in drug development, traditionally achieved through high-throughput screening (HTS). Newer methods such as DNA-Encoded Libraries (DEL) and Affinity Selection Mass Spectrometry (ASMS) offer large-scale, cost-effective alternatives. However, they… read more here.
Keywords: chemistry; discovery; hit discovery; platform ... See more keywords