A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00682
Abstract: Autophagy-related proteins (Atgs) drive the lysosome-mediated degradation pathway, autophagy, to enable the clearance of dysfunctional cellular components and maintain homeostasis. In humans, this process is driven by the mammalian Atg8 (mAtg8) family of proteins comprising… read more here.
Keywords: reveals novel; multifaceted hit; family; approach reveals ... See more keywords
5,5- and 5,6-Membered Spirocyclic Indolinone Hit-Finding Libraries.
Sign Up to like & getrecommendations! Published in 2019 at "ACS combinatorial science"
DOI: 10.1021/acscombsci.9b00057
Abstract: The production of two libraries based on spirocyclic indolinones is described. These libraries were selected from numerous spirocyclic indolinone scaffolds with a library evaluation procedure used routinely at Novartis, based on computed physicochemical properties and… read more here.
Keywords: indolinone; finding libraries; membered spirocyclic; hit finding ... See more keywords
Abstract B037: Hit-finding by Cysteine-Scanning (HCS): A method for finding druggable pockets
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-b037
Abstract: Large-scale cancer sequencing efforts coupled with deep functional genomic interrogation of cancer models provides us an increasingly detailed view of the critical cancer drivers required for persistent growth and survival of cancer cells. Targeting such… read more here.
Keywords: finding cysteine; hcs; hit finding; cysteine scanning ... See more keywords