The link between microglia and the severity of COVID‐19: The “two‐hit” hypothesis
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DOI: 10.1002/jmv.26984
Abstract: Highlights Neurological manifestations constitute a serious cause of severe coronavirus disease 2019 (COVID‐19). Microglial hyperactivation by the two‐hit process. Severe COVID‐19 patients carry pre‐activated microglia following a first immune challenge. Exaggerated response of sensitized microglia… read more here.
Keywords: covid two; microglia severity; link microglia; hit hypothesis ... See more keywords
Second hit hypothesis in dystonia: Dysfunctional cross talk between neuroplasticity and environment?
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DOI: 10.1016/j.nbd.2021.105511
Abstract: One of the great mysteries in dystonia pathophysiology is the role of environmental factors in disease onset and development. Progress has been made in defining the genetic components of dystonic syndromes, still the mechanisms behind… read more here.
Keywords: second hit; dystonia; evidence; hit hypothesis ... See more keywords
Stage 1 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: protocol for a test of the double hit hypothesis
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DOI: 10.12688/wellcomeopenres.13828.2
Abstract: Background: The presence of an extra sex chromosome is associated with an increased rate of neurodevelopmental difficulties involving language. Group averages, however, obscure a wide range of outcomes. Hypothesis: The 'double hit' hypothesis proposes that… read more here.
Keywords: hit hypothesis; double hit; sex; sex chromosome ... See more keywords
Stage 2 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: testing the double hit hypothesis.
Sign Up to like & getrecommendations! Published in 2018 at "Wellcome open research"
DOI: 10.12688/wellcomeopenres.14677.1
Abstract: Background: The presence of an extra sex chromosome is associated with an increased rate of neurodevelopmental difficulties involving language. The 'double hit' hypothesis proposes that the adverse impact of the extra sex chromosome is amplified… read more here.
Keywords: double hit; children sex; sex chromosome; sex ... See more keywords