Single-hit inactivation drove tumor suppressor genes out of the X chromosome during evolution.
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DOI: 10.1158/0008-5472.can-21-3458
Abstract: Cancer-related genes are under intense evolutionary pressure. In this study, we conjecture that X-linked tumor suppressor genes (TSG) are not protected by the Knudson's two-hit mechanism and are therefore subject to negative selection. Accordingly, nearly… read more here.
Keywords: suppressor genes; single hit; tumor suppressor; hit inactivation ... See more keywords