Platelet factor 4 triggers thrombo-inflammation by bridging innate and adaptive immunity.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.14075
Abstract: Platelet factor 4 (PF4, synonym: CXCL4) is an evolutionary old chemokine with proposed roles in hemostasis and antimicrobial defense. In addition, PF4 has attracted considerable attention as a crucial mediator of one of the most… read more here.
Keywords: hit vitt; vitt antibodies; pf4; platelet ... See more keywords
Off-the-shelf cryopreserved platelets for the detection of HIT and VITT antibodies.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022017283
Abstract: Heparin-induced thrombocytopenia (HIT) is suspected much more often than it is confirmed. Technically-simple Platelet Factor-4 (PF4)-polyanion enzyme-linked immunosorbent assays (ELISAs) are sensitive but non-specific. In contrast, accurate functional tests such as the serotonin release assay,… read more here.
Keywords: hit vitt; heparin; vitt antibodies; release ... See more keywords