Anti-HIV-active Nucleoside Triphosphate Prodrugs.
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DOI: 10.1021/acs.jmedchem.0c00271
Abstract: We disclose a study on nucleoside triphosphate (NTP) analogues in which the γ-phosphate is covalently modified by F8butwo different biodegradable masking units and d4T as nucleoside analogue that enable the delivery of d4TTP with high… read more here.
Keywords: active nucleoside; hiv active; chemistry; triphosphate prodrugs ... See more keywords
Triphosphate Prodrugs of the Anti-HIV-Active Compound 3'-Deoxy-3'-fluorothymidine (FLT).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00665
Abstract: 3'-Fluoro-3'-deoxythymidine (FLT) was identified as one of the most potent inhibitors of human immunodeficiency virus (HIV) replication. However, FLT also showed severe toxicity so that it was abundant as a potential chemotherapeutic agent. Here, we… read more here.
Keywords: triphosphate prodrugs; flt; hiv active; prodrugs anti ... See more keywords