Prediction of anti‐HIV activity on the basis of stacked auto‐encoder
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemometrics"
DOI: 10.1002/cem.2916
Abstract: The prediction of biologically active compounds plays a very important role for high‐throughput screening approaches in drug discovery. Most computational models, in this area, concentrate on measuring structural similarities between chemical elements. There are various… read more here.
Keywords: hiv activity; auto encoder; anti hiv; stacked auto ... See more keywords
Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700141
Abstract: Human immunodeficiency virus type 1 (HIV‐1) nucleocapsid protein 7 (NCp7), a zinc finger protein, plays critical roles in viral replication and maturation and is an attractive target for drug development. However, the development of drug‐like molecules that… read more here.
Keywords: anti hiv; nucleocapsid protein; hiv activity; activity ... See more keywords
Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.020
Abstract: In this study, 12 known cycloartane triterpenoids (1-12) with four different skeletons isolated from the roots of Souliea vaginata were screened for the first time for in vitro anti-HIV activity using AZT as a standard. Among… read more here.
Keywords: synthesis novel; hiv activity; discovery synthesis; hiv ... See more keywords
Discovery of 2-isoxazol-3-yl-acetamide analogues as heat shock protein 90 (HSP90) inhibitors with significant anti-HIV activity.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111699
Abstract: The recent burst of explorations on heat shock protein 90 (HSP90) in virus research supports its emergence as a promising target to overcome the drawbacks of current antiviral therapeutic regimen. In continuation of our efforts… read more here.
Keywords: hsp90; hiv activity; hiv; heat shock ... See more keywords
Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Ethnopharmacology"
DOI: 10.1016/j.jep.2017.08.005
Abstract: Abstract Ethnopharmacological relevance The African continent is home to a large number of higher plant species used over centuries for many applications, which include treating and managing diseases such as HIV. Due to the overwhelming… read more here.
Keywords: use; hiv activity; southern african; hiv ... See more keywords
Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.9b00779
Abstract: Combination antiretroviral therapy is the mainstay of HIV treatment, lowering plasma viral levels below detection. However, eradication of HIV is a major challenge due to cellular and anatomical viral reservoirs that are often protected from… read more here.
Keywords: trojan horse; hiv activity; hiv; anti hiv ... See more keywords
Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.0c00540
Abstract: Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis.… read more here.
Keywords: anti hiv; hiv activity; daphne odora; daphnane diterpenoids ... See more keywords
Constituents of Croton megalocarpus with Potential Anti-HIV Activity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c01013
Abstract: Reported herein is an anti-HIV monochlorinated compound, 1β-acetoxy-3β-chloro-5α,6α-dihydroxycrotocascarin L (1), of the rare crotofolane diterpenoid class. Compound 1, a suspected artifact of extraction, along with the previously undescribed 11β-acetoxycrotocascarin L (2) and a known compound,… read more here.
Keywords: anti hiv; constituents croton; hiv activity; croton megalocarpus ... See more keywords
Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00894
Abstract: From the whole plant of Daphne pedunculata, 12 macrocyclic daphnane diterpenoids, including six new compounds, daphnepedunins A-F (1-4, 9, and 10), were isolated. Their structures were elucidated by physiochemical and spectroscopic data analysis, the modified… read more here.
Keywords: hiv activity; anti hiv; daphne pedunculata; macrocyclic daphnane ... See more keywords
Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01933
Abstract: CXCL12 is a chemotactic cytokine that attracts many different cell types for homeostasis and during inflammation. Under stress conditions, macrophages and granulocytes produce factors such as peroxynitrite as a consequence of their oxidative response. After… read more here.
Keywords: hiv activity; nt7 cxcl12; lymphocyte extravasation; cxcl12 ... See more keywords
Anti-HIV Activity of Snake Venom Phospholipase A2s: Updates for New Enzymes and Different Virus Strains
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031610
Abstract: Since the beginning of the HIV epidemic, lasting more than 30 years, the main goal of scientists was to develop effective methods for the prevention and treatment of HIV infection. Modern medicines have reduced the… read more here.
Keywords: hiv activity; anti hiv; snake pla2s; activity ... See more keywords