Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28250-7
Abstract: Increasingly, antibodies are being used to treat and prevent viral infections. In the context of HIV, efficacy is primarily attributed to dose-dependent neutralization potency and to a lesser extent Fc-mediated effector functions. It remains unclear… read more here.
Keywords: hiv antibody; antibody; antibody associated; effector functions ... See more keywords
The impact of proline isomerization on antigen binding and the analytical profile of a trispecific anti-HIV antibody
Sign Up to like & getrecommendations! Published in 2019 at "mAbs"
DOI: 10.1080/19420862.2019.1698128
Abstract: ABSTRACT Proline cis-trans conformational isomerization is a mechanism that affects different types of protein functions and behaviors. Using analytical characterization, structural analysis, and molecular dynamics simulations, we studied the causes of an aberrant two-peak size-exclusion… read more here.
Keywords: hiv antibody; antibody; isomerization; trispecific anti ... See more keywords
Structural Insights from HIV-Antibody Coevolution and Related Immunization Studies.
Sign Up to like & getrecommendations! Published in 2018 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2018.0097
Abstract: Human immunodeficiency virus type 1 (HIV-1) is a rapidly evolving pathogen that causes acquired immunodeficiency syndrome (AIDS) in humans. There are ∼30-35 million people infected with HIV around the world, and ∼25 million have died… read more here.
Keywords: hiv antibody; hiv; insights hiv; immunization studies ... See more keywords
Broadly neutralizing HIV-1 antibody reactivity in HIV tests: implications for diagnostics.
Sign Up to like & getrecommendations! Published in 2021 at "AIDS"
DOI: 10.1097/qad.0000000000002898
Abstract: OBJECTIVE Passive immunization with broadly neutralizing antibodies (bNAbs) is under evaluation for HIV prevention. BNAbs target gp120 or gp41, two HIV envelope antigens commonly present in diagnostic tests. Depending on bNAb type and dose administered… read more here.
Keywords: broadly neutralizing; hiv; hiv tests; bnabs ... See more keywords
Collaborative Study to Establish National Reference Standards for Anti-HIV-1 Antibody
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Laboratory Medicine"
DOI: 10.3343/alm.2023.43.3.273
Abstract: Background National reference standards for anti-HIV-1 antibody are needed to evaluate the performance and maintain the quality control of anti-HIV-1 antibody assays. The aim of this study was to prepare a mixed-titer performance panel and… read more here.
Keywords: hiv antibody; anti hiv; national reference;