Discovery of novel 1,2,4‐triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28064
Abstract: Human immunodeficiency virus (HIV) capsid (CA) protein is a promising target for developing novel anti‐HIV drugs. Starting from highly anticipated CA inhibitors PF‐74, we used scaffold hopping strategy to design a series of novel 1,2,4‐triazole… read more here.
Keywords: capsid protein; novel triazole; hiv; hiv capsid ... See more keywords
Structure-based virtual screening workflow to identify antivirals targeting HIV-1 capsid
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-022-00446-5
Abstract: We have identified novel HIV-1 capsid inhibitors targeting the PF74 binding site. Acting as the building block of the HIV-1 capsid core, the HIV-1 capsid protein plays an important role in the viral life cycle… read more here.
Keywords: structure based; screening workflow; capsid; hiv capsid ... See more keywords
Structure-based insights into the mechanism of nucleotide import by HIV-1 capsid.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2019.05.001
Abstract: Nucleotide import is critical to the reverse transcription and thus a key step in the life cycle of HIV-1 virus. In this work, boosted by the recently determined atomic structure of the whole HIV-1 capsid… read more here.
Keywords: mechanism; hiv; nucleotide import; hiv capsid ... See more keywords
A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model
Sign Up to like & getrecommendations! Published in 2019 at "Nature Medicine"
DOI: 10.1038/s41591-019-0560-x
Abstract: People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication fatigue that might lead to suboptimal treatment adherence and the emergence of… read more here.
Keywords: long acting; molecule hiv; small molecule; hiv capsid ... See more keywords
Uracil derivatives as HIV-1 capsid protein inhibitors: design, in silico, in vitro and cytotoxicity studies
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02450k
Abstract: A series of novel uracil derivatives such as bispyrimidine dione and tetrapyrimidine dione derivatives were designed based on the existing four-point pharmacophore model as effective HIV capsid protein inhibitors. The compounds were initially docked with… read more here.
Keywords: hiv capsid; capsid protein; uracil derivatives; protein inhibitors ... See more keywords
The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202815120
Abstract: Increasing evidence has suggested that the HIV-1 capsid enters the nucleus in a largely assembled, intact form. However, not much is known about how the cone-shaped capsid interacts with the nucleoporins (NUPs) in the nuclear… read more here.
Keywords: capsid lattice; hiv; hiv capsid; hiv cores ... See more keywords
Molecular dynamics and DFT study on the structure and dynamics of N-terminal domain HIV-1 capsid inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Simulation"
DOI: 10.1080/08927022.2019.1674850
Abstract: ABSTRACT HIV-1 infection is a major threat in the world and has drawn much attention. The emergence of drug-resistance to most of the HIV-1 inhibitors has led to the crucial call for new inhibitors that… read more here.
Keywords: terminal domain; molecular dynamics; domain hiv; hiv ... See more keywords
The discovery and design of novel HIV-1 capsid modulators and future perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2023.2157401
Abstract: ABSTRACT Introduction Although combination antiretroviral therapy (cART) has achieved significant success in treating HIV, the emergence of multidrug-resistant viruses and cumulative medication toxicity make it necessary to find new classes of antiretroviral agents with novel… read more here.
Keywords: hiv capsid; design; discovery design; hiv ... See more keywords
The HIV-1 Capsid-Targeted Inhibitor GSK878 Alters Selection of Target Sites for HIV DNA Integration.
Sign Up to like & getrecommendations! Published in 2023 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2022.0161
Abstract: Decades of effort have yielded highly effective antiviral agents to treat HIV, but viral strains have evolved resistance to each inhibitor type, focusing attention on the importance of developing new inhibitor classes. A particularly promising… read more here.
Keywords: hiv capsid; integration; inhibitor; target sites ... See more keywords
Selection and identification of an RNA aptamer that specifically binds the HIV-1 capsid lattice and inhibits viral replication
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1293
Abstract: Abstract The HIV-1 capsid core participates in several replication processes. The mature capsid core is a lattice composed of capsid (CA) monomers thought to assemble first into CA dimers, then into ∼250 CA hexamers and… read more here.
Keywords: hiv capsid; aptamer specifically; replication; lattice ... See more keywords
Lenacapavir and the novel HIV-1 capsid inhibitors: an emerging therapy in the management of multidrug-resistant HIV-1 virus
Sign Up to like & getrecommendations! Published in 2023 at "Current Opinion in Infectious Diseases"
DOI: 10.1097/qco.0000000000000896
Abstract: Purpose of review The aim of this study was to summarize current evidence regarding lenacapavir, a first in class HIV-1 capsid inhibitor, and its role as an emergent therapy for the treatment of HIV-1 infection.… read more here.
Keywords: hiv; hiv capsid; capsid inhibitors; therapy ... See more keywords