Amino acids at positions 3, 168, and 169 are associated with the ability of Nef proteins from HIV‐1 CRF01_AE to downmodulate CD4
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24851
Abstract: Several HIV‐1 subtypes are co‐circulating among various high‐risk groups in China, and an increasing prevalence of CRF01_AE was observed among MSM (men who have sex with men) within recent years. Patients infected with CRF01_AE may… read more here.
Keywords: positions 168; hiv crf01; nef proteins; disease progression ... See more keywords
Effect of Amino Acid Substitutions Within the V3 Region of HIV-1 CRF01_AE on Interaction with CCR5-Coreceptor.
Sign Up to like & getrecommendations! Published in 2017 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2017.0044
Abstract: Specific amino acids within the V3 loop of HIV-1 CRF01_AE envelope glycoprotein that are involved in the interaction with CCR5/CXCR4 coreceptors, are not well characterized. We generated V3 mutants using polymerase chain reaction (PCR)-based site-directed… read more here.
Keywords: interaction ccr5; coreceptor; hiv crf01;
Rapid CD4+ T-cell decline is associated with coreceptor switch among MSM primarily infected with HIV-1 CRF01_AE in Northeast China
Sign Up to like & getrecommendations! Published in 2019 at "AIDS"
DOI: 10.1097/qad.0000000000001981
Abstract: Objective: CRF01_AE is the most prevalent HIV-1 subtype among MSM in China. However, the characteristics and underlying mechanism of the accelerated CD4+ T-cell decline in CRF01_AE-infected MSM remain incompletely understood. Design: A long-term prospective follow-up… read more here.
Keywords: crf01; coreceptor switch; cell decline; cd4 cell ... See more keywords
P148 Transcontinental dissemination of the major HIV-1 CRF01_AE lineages circulating in china
Sign Up to like & getrecommendations! Published in 2019 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2019-sti.313
Abstract: Background While HIV-1 CRF01_AE has caused a large epidemic in Mainland China, and distinct lineages related to transmission among various high-risk populations have been identified, whether its transmissions have dispersal outside remains poorly understood. We… read more here.
Keywords: mainland china; hiv; hiv crf01; crf01 lineages ... See more keywords
Analysis of temporal changes in HIV-1 CRF01_AE gag genetic variability and CD8 T-cell epitope evolution
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0267130
Abstract: Currently, little is known about the time-dependent evolution of human immunodeficiency virus-1 (HIV-1) circulating recombinant forms (CRF) 01_AE, a dominant recombinant form associated with HIV-1 epidemics worldwide. Since gag is a highly immunodominant HIV-1 protein,… read more here.
Keywords: variability; crf01; hiv crf01; crf01 gag ... See more keywords
The Molecular Epidemiological and Immunological Characteristics of HIV-1 CRF01_AE/B Recombinants in Nanjing, China
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.936502
Abstract: Human immunodeficiency virus-type 1 (HIV-1) CRF01_AE/B recombinants are newly emerging strains that are spreading rapidly in Southern and Eastern China. This study aimed to elucidate the molecular epidemiological characteristics of HIV-1 CRF01_AE/B recombinants in Nanjing… read more here.
Keywords: recombinants nanjing; crf01 recombinants; molecular epidemiological; characteristics hiv ... See more keywords