Differences in HIV cure clinical trial preferences of French people living with HIV and physicians in the ANRS‐APSEC study: a discrete choice experiment
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25443
Abstract: Despite the advent of HIV cure‐related clinical trials (HCRCT) for people living with HIV (PLWH), the risks and uncertainty involved raise ethical issues. Although research has provided insights into the levers and barriers to PLWH… read more here.
Keywords: clinical trial; differences hiv; cure clinical; hiv cure ... See more keywords
Tools for Visualizing HIV in Cure Research
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DOI: 10.1007/s11904-018-0376-1
Abstract: Purpose of ReviewThe long-lived HIV reservoir remains a major obstacle for an HIV cure. Current techniques to analyze this reservoir are generally population-based. We highlight recent developments in methods visualizing HIV, which offer a different,… read more here.
Keywords: visualizing hiv; hiv; hiv cure; hiv reservoir ... See more keywords
The current state of an HIV cure: innovative approaches and limitations
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.04.020
Abstract: HIV has accounted formore than 35million deaths globally since the HIV/AIDS epidemic began in 1981. According to the latest UNAIDS figures, at the end of 2017, an estimated 36·9 million people were living with HIV.… read more here.
Keywords: cart; reservoir; hiv; hiv cure ... See more keywords
NF-κB sub-pathways and HIV cure: A revisit
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DOI: 10.1016/j.ebiom.2020.103159
Abstract: HIV cure is thwarted by the presence of quiescent yet replication competent HIV-1 (HIV). Antiretroviral therapy (ART) is unable to eradicate reservoirs, and upon cessation of ART, HIV will rebound. This review encompasses the curative… read more here.
Keywords: hiv; pathways hiv; hiv cure; cure ... See more keywords
High frequency of CD8 escape mutations in elite controllers as new obstacle for HIV cure
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2129353
Abstract: ABSTRACT Accumulation of mutations in epitopes of cytolytic-T-lymphocytes immune response (CTL) in HIV-reservoir seems to be one of the reasons for shock-and-kill strategy failure. Ten non-controller patients on successful cART (TX) and seven elite controllers… read more here.
Keywords: elite controllers; hiv; escape mutations; hiv gag ... See more keywords
Managing Expectations of an HIV Cure: What Should We Expect?
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DOI: 10.1089/aid.2017.0247
Abstract: Th is pa pe r h as b ee n pe er -re vi ew ed a nd a cc ep te d fo r p ub lic at io n, b ut h as… read more here.
Keywords: managing expectations; cure expect; hiv cure; cure ... See more keywords
Time to Engage Young People in HIV Cure Research.
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DOI: 10.1089/aid.2020.0268
Abstract: Antiretroviral treatments successfully suppress and control HIV but cannot eliminate the virus. In recent years, much research has gone into developing a cure for HIV. This research comes with significant risks and limited clinical benefits… read more here.
Keywords: hiv cure; cure research; cure; young people ... See more keywords
Considerations for Increasing Racial, Ethnic, Gender and Sexual Diversity in HIV Cure-Related Research with Analytical Treatment Interruptions: A Qualitative Inquiry.
Sign Up to like & getrecommendations! Published in 2021 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2021.0023
Abstract: BACKGROUND Despite disproportionate incidence and prevalence of HIV among transgender individuals, cisgender women, and racial and ethnic minority groups, all remain under-represented in HIV cure research. As HIV cure trials are scaled up, there is… read more here.
Keywords: hiv cure; ati trials; cure; racial ethnic ... See more keywords
Willingness of older Canadians with HIV to participate in HIV cure research near and after the end-of-life: A mixed-method study.
Sign Up to like & getrecommendations! Published in 2022 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2022.0006
Abstract: INTRODUCTION HIV cure research requires interrogating latent HIV reservoirs in deep tissues, which necessitates autopsies to avoid risks to participants. An HIV autopsy biobank would facilitate this research, but such research raises ethical issues and… read more here.
Keywords: end life; research; cure research; hiv cure ... See more keywords
Vulnerability in biomedical research: a historical reflection and practical implications for HIV cure-related research.
Sign Up to like & getrecommendations! Published in 2023 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2022.0136
Abstract: Background The concept of vulnerability in bioethics was first referenced in 1979, when the Belmont Report highlighted the need for special consideration of certain populations in the application of its general principles of respect for… read more here.
Keywords: vulnerability; practical implications; vulnerability biomedical; hiv cure ... See more keywords
Engaging cell and gene therapists in HIV cure.
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DOI: 10.1089/hum.2020.236
Abstract: Cell and gene therapy (CGT) has a variety of potential applications in human immunodeficiency virus (HIV) prevention and management. The existing network of CGT researchers for HIV cure will benefit from an influx of fresh… read more here.
Keywords: hiv cure; gene; cell gene; engaging cell ... See more keywords