Elimination of infectious HIV DNA by CRISPR–Cas9
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2019.07.001
Abstract: Current antiretroviral drugs can efficiently block HIV replication and prevent transmission, but do not target the HIV provirus residing in cells that constitute the viral reservoir. Because drug therapy interruption will cause viral rebound from… read more here.
Keywords: hiv dna; dna; crispr cas9; hiv ... See more keywords
Extremely low viral reservoir in treated chronically HIV-1-infected individuals
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102830
Abstract: Background Small viral reservoirs are found predominantly in HIV-1 controllers and individuals treated during acute/early HIV-1 infection. However, other HIV+ individuals could naturally also harbour low viral reservoirs. Methods We screened 451 HIV-1-infected treated-individuals with… read more here.
Keywords: hiv dna; viral reservoir; hiv; low viral ... See more keywords
Comparative analysis and generation of a robust HIV-1 DNA quantification assay.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2018.10.010
Abstract: HIV-1 infection cannot be cured due to the presence of the latent reservoir (LR). Novel cure or treatment strategies, such as "shock and kill" or therapeutic vaccination, aim to reduce or eradicate the LR. Cure… read more here.
Keywords: hiv dna; dna; dna quantification; analysis ... See more keywords
Progress Towards a Therapeutic HIV DNA Vaccine
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DOI: 10.1080/14760584.2022.2059467
Abstract: ABSTRACT Introduction Antiretroviral therapy (ART) reduces HIV replication to undetectable levels and prevents AIDS but cannot cure the infection and discontinuing ART results in viral rebound. Therefore, a primary goal of HIV therapeutic vaccine research… read more here.
Keywords: dna; hiv; dna vaccine; therapeutic hiv ... See more keywords
Quantification of Residual Germinal Center Activity and HIV-1 DNA and RNA Levels Using Fine Needle Biopsies of Lymph Nodes During Antiretroviral Therapy.
Sign Up to like & getrecommendations! Published in 2017 at "AIDS Research and Human Retroviruses"
DOI: 10.1089/aid.2016.0171
Abstract: Abstract HIV-1 reservoirs are most often studied in peripheral blood (PB), but not all lymphocytes recirculate, particularly T follicular helper (Tfh) CD4+ T cells, as well as germinal center (GC) B cells, in lymph nodes… read more here.
Keywords: hiv dna; germinal center; lymph nodes; hiv ... See more keywords
HIV-1 DNA Is Maintained in Antigen-Specific CD4+ T Cell Subsets in Patients on Long-Term Antiretroviral Therapy Regardless of Recurrent Antigen Exposure.
Sign Up to like & getrecommendations! Published in 2019 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2018.0235
Abstract: Memory CD4+ T cells (mCD4s) containing integrated HIV DNA are considered the main barrier to a cure for HIV infection. Here, we analyzed HIV DNA reservoirs in antigen-specific subsets of mCDs to delineate the mechanisms… read more here.
Keywords: antigen specific; hiv; specific mcd4s; hiv dna ... See more keywords
Dynamics of drug resistance-associated mutations in HIV-1 DNA reverse transcriptase sequence during effective ART
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dky130
Abstract: Objectives To investigate the dynamics of HIV-1 variants archived in cells harbouring drug resistance-associated mutations (DRAMs) to lamivudine/emtricitabine, etravirine and rilpivirine in patients under effective ART free from selective pressure on these DRAMs, in order… read more here.
Keywords: hiv dna; drug resistance; resistance; resistance associated ... See more keywords
HIV-1 DNA Testing in Viremic Patients Identifies More Drug Resistance Than HIV-1 RNA Testing
Sign Up to like & getrecommendations! Published in 2023 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofad146
Abstract: Abstract Background The Department of Health and Human Services HIV-1 Treatment Guidelines recommend drug resistance testing in HIV-1 RNA to guide the selection of antiretroviral therapy in patients with viremia. However, resistance-associated mutations (RAMs) in… read more here.
Keywords: hiv dna; drug; resistance; hiv rna ... See more keywords
HIV DNA decay during antiretroviral therapy: lessons from a clinic-based cohort study.
Sign Up to like & getrecommendations! Published in 2018 at "AIDS"
DOI: 10.1097/qad.0000000000001949
Abstract: Antiretroviral therapy (ART) suppresses HIV replication, which leads to plasma viral loads (pVLs) below the limit of quantification in the majority of treated people. Despite suppression of plasma viremia, however, a latent HIV reservoir persists… read more here.
Keywords: hiv dna; antiretroviral therapy; dna decay;
Immune checkpoint inhibitors in people living with HIV: what about anti-HIV effects?
Sign Up to like & getrecommendations! Published in 2019 at "AIDS"
DOI: 10.1097/qad.0000000000002397
Abstract: : Immune checkpoint inhibitors (ICPi) have shown major therapeutic successes when used in various cancers. In the HIV field a double benefit of such ICPi should result from their dual ability to restore in-vitro HIV-specific… read more here.
Keywords: specific cd8; hiv dna; immune checkpoint; hiv ... See more keywords
Predictors of intact HIV DNA levels among children in Kenya.
Sign Up to like & getrecommendations! Published in 2023 at "AIDS"
DOI: 10.1097/qad.0000000000003499
Abstract: OBJECTIVE We determined predictors of both intact (estimate of replication-competent) and total (intact and defective) HIV DNA in the reservoir among children with HIV. DESIGN HIV DNA in the reservoir was quantified longitudinally in children… read more here.
Keywords: predictors intact; dna; among children; hiv dna ... See more keywords