The prevalence of pre‐treatment and acquired HIV drug resistance in Vietnam: a nationally representative survey, 2017–2018
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25857
Abstract: Monitoring the population‐level emergence and transmission of HIV drug resistance (HIVDR) is necessary for supporting public health programmes. This study provides a nationally representative prevalence estimate of HIVDR in people initiating antiretroviral therapy (ART) and… read more here.
Keywords: drug resistance; nationally representative; hiv drug; prevalence ... See more keywords
New targets for HIV drug discovery.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.03.013
Abstract: Recent estimates suggest close to one million people per year die globally owing to HIV-related illnesses. Therefore, there is still a need to identify new targets to develop future treatments. Many of the more recently… read more here.
Keywords: targets hiv; drug; new targets; hiv drug ... See more keywords
HIV drug resistance testing – The quest for Point-of-Care
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.11.040
Abstract: The fight against a Human Immunodeficiency Virus (HIV) pandemic is progressively advancing towards the ambitious 90-90-90 goal: to diagnose HIV infection in 90% of infected subjects, provide treatment to 90% of those and, finally, achieving… read more here.
Keywords: drug resistance; testing quest; drug; resistance testing ... See more keywords
Management of Virologic Failure and HIV Drug Resistance
Sign Up to like & getrecommendations! Published in 2019 at "Infectious Disease Clinics of North America"
DOI: 10.1016/j.idc.2019.05.004
Abstract: Approximately 20% of people with HIV in the United States prescribed antiretroviral therapy are not virally suppressed. Thus, optimal management of virologic failure has a critical role in the ability to improve viral suppression rates… read more here.
Keywords: hiv drug; virologic failure; resistance; failure ... See more keywords
Application of next generation sequencing in HIV drug resistance studies in Africa, 2005–2019: A systematic review
Sign Up to like & getrecommendations! Published in 2021 at "Scientific African"
DOI: 10.1016/j.sciaf.2021.e00829
Abstract: Abstract The control of HIV transmission is a high priority for Africa, in line with Agenda 2063 of the African Union. The development of HIV drug resistance poses a significant challenge in maintaining suppressed viral… read more here.
Keywords: next generation; hiv drug; generation sequencing; drug resistance ... See more keywords
The characteristics of pretreatment HIV-1 drug resistance in western Yunnan, China
Sign Up to like & getrecommendations! Published in 2020 at "Epidemiology and Infection"
DOI: 10.1017/s095026882000093x
Abstract: Abstract HIV-1 drug resistance can compromise the effectiveness of antiretroviral therapy (ART). A survey of pretreatment HIV-1 drug resistance (PDR) was conducted in Lincang Prefecture of Yunnan Province. From 372 people living with HIV/AIDS initiating… read more here.
Keywords: hiv drug; western yunnan; resistance; drug resistance ... See more keywords
A MiSeq-HyDRA platform for enhanced HIV drug resistance genotyping and surveillance
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45328-3
Abstract: Conventional HIV drug resistance (HIVDR) genotyping utilizes Sanger sequencing (SS) methods, which are limited by low data throughput and the inability of detecting low abundant drug resistant variants (LADRVs). Here we present a next generation… read more here.
Keywords: miseq hydra; hiv drug; platform;
Performance comparison of next generation sequencing analysis pipelines for HIV-1 drug resistance testing
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-58544-z
Abstract: Next generation sequencing (NGS) is a trending new standard for genotypic HIV-1 drug resistance (HIVDR) testing. Many NGS HIVDR data analysis pipelines have been independently developed, each with variable outputs and data management protocols. Standardization… read more here.
Keywords: drug resistance; analysis; analysis pipelines; hiv drug ... See more keywords
Ultra-Deep Sequencing Analysis on HIV Drug-Resistance-Associated Mutations Among HIV-Infected Individuals: First Report from the Philippines.
Sign Up to like & getrecommendations! Published in 2017 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2016.0151
Abstract: A sharp increase in the number of people living with HIV has been documented in the Philippines. In response, the government has instituted antiretroviral therapy (ART) nationwide through HIV treatment hubs. However, no data presently… read more here.
Keywords: drug resistance; hiv; drug; resistance associated ... See more keywords
External Quality Assessment Scheme for HIV-1 Drug-Resistance Genotyping in Thailand.
Sign Up to like & getrecommendations! Published in 2018 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2017.0299
Abstract: The efficacy of antiretroviral (ARV) therapy can be compromised by the emergence and transmission of HIV-1 drug-resistant strains. HIV-1 drug-resistance (DR) genotypic testing thus plays an important role in the selection of optimal treatment regimens… read more here.
Keywords: drug resistance; drug; quality assessment; external quality ... See more keywords
HIV-1 drug resistance mutation analyses of Cameroon derived Integrase sequences.
Sign Up to like & getrecommendations! Published in 2020 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2020.0022
Abstract: HIV-1 Integrase (IN) is a primary target for combination antiretroviral therapy (cART). Only a limited number of studies report on the emergence of resistance-associated mutations (RAMs) in Cameroon. We observed that (1.4%) of sequence from… read more here.
Keywords: hiv drug; cameroon; resistance mutation; resistance ... See more keywords