Accelerating investigation of new HIV drugs in pregnancy: advancing the research agenda from theory to action
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25912
Abstract: Historical approaches to clinical development of novel therapeutics for treatment and prevention of HIV have led to unacceptable delays in the generation of data to support optimal antiretroviral drug use in pregnancy. Over the last… read more here.
Keywords: accelerating investigation; hiv; investigation new; pregnancy ... See more keywords
Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 1: Model for the Free-drug Mixture.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2021.10.007
Abstract: Drug-combination nanoparticles (DcNP) is a nano-formulation of multiple HIV drugs in one injectable. DcNP demonstrated long-acting pharmacokinetics (PK) for all drugs in the blood and lymphatic system of nonhuman primates (NHP). Long-acting is due to… read more here.
Keywords: hiv drugs; part; system; free drug ... See more keywords
A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.00486-20
Abstract: Understanding the mechanism of HIV-1 resistance to anti-HIV-1 drugs could lead to the development of novel drugs with increased efficiency, resulting in more effective ART. ART composed of more potent and long-acting anti-HIV-1 drugs can… read more here.
Keywords: anti hiv; hiv drugs; hiv; hiv rna ... See more keywords
Nef Suppresses LINE-1 Retrotransposition through Two Distinct Mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01148-22
Abstract: Human immunodeficiency viruses are pathogens of AIDS that were first discovered almost 40 years ago and continue to threaten human lives to date. While currently used anti-HIV drugs are sufficient to suppress viral loads in HIV-infected… read more here.
Keywords: hiv; anti hiv; hiv drugs; line ... See more keywords
P237 Enzyme complexes of alcohol metabolism protect against liver injury in animal models fed acute alcohol and anti-HIV drugs
Sign Up to like & getrecommendations! Published in 2019 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2019-sti.373
Abstract: Background A significant portion of AIDS patients under anti-HIV therapies consume or abuse alcohol, which causes liver injuries. This study was to evaluate effects of eliminating blood alcohol on anti-HIV drugs and alcohol-induced liver injuries… read more here.
Keywords: acute alcohol; hiv drugs; anti hiv; enzyme nanoparticles ... See more keywords
Novel Approaches for the Delivery of Anti-HIV Drugs-What Is New?
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics11110554
Abstract: HIV/AIDS continues to be one of the most challenging individual and public health concerns of our days [...] read more here.
Keywords: anti hiv; novel approaches; hiv drugs; hiv ... See more keywords