CXCR4‐targeting nanobodies differentially inhibit CXCR4 function and HIV entry
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.10.015
Abstract: &NA; The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human diseases, such as cancer. CXCR4 is also a major co‐receptor facilitating HIV entry. Accordingly, CXCR4 is considered as an attractive… read more here.
Keywords: hiv entry; cxcr4 targeting; activity; targeting nanobodies ... See more keywords
Soybean-derived Bowman-Birk inhibitor (BBI) blocks HIV entry into macrophages.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2017.08.030
Abstract: Bowman-Birk inhibitor (BBI) is a soybean-derived protease inhibitor that has anti-inflammation and anti-HIV effect. Here, we further investigated the anti-HIV action of BBI in macrophages, focusing on its effect on viral entry. We found that… read more here.
Keywords: birk inhibitor; hiv entry; bowman birk; entry ... See more keywords
Bivalent Ligand Aiming Putative Mu Opioid Receptor and Chemokine Receptor CXCR4 Dimers in Opioid Enhanced HIV-1 Entry.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00444
Abstract: A bivalent compound 1a featuring both a mu opioid receptor (MOR) and a CXCR4 antagonist pharmacophore (naltrexone and IT1t) was designed and synthesized. Further binding and functional studies demonstrated 1a acting as a MOR and… read more here.
Keywords: cxcr4; mor cxcr4; bivalent ligand; receptor ... See more keywords
Design of a Bispecific HIV Entry Inhibitor Targeting the Cell Receptor CD4 and Viral Fusion Protein Gp41
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.916487
Abstract: Given the high variability and drug-resistance problem by human immunodeficiency virus type 1 (HIV-1), the development of bispecific or multi-specific inhibitors targeting different steps of HIV entry is highly appreciated. We previously generated a very… read more here.
Keywords: cell; fusion; hiv; hiv entry ... See more keywords
The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18071575
Abstract: Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people… read more here.
Keywords: 5p12 rantes; hiv entry; cyclization; terminal cyclization ... See more keywords
Active Components from Cassia abbreviata Prevent HIV-1 Entry by Distinct Mechanisms of Action
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22095052
Abstract: Cassia abbreviata is widely used in Sub-Saharan Africa for treating many diseases, including HIV-1 infection. We have recently described the chemical structures of 28 compounds isolated from an alcoholic crude extract of barks and roots… read more here.
Keywords: cassia abbreviata; hiv entry; infection; entry ... See more keywords
Virtual Screening, Biological Evaluation, and 3D-QSAR Studies of New HIV-1 Entry Inhibitors That Function via the CD4 Primary Receptor
Sign Up to like & getrecommendations! Published in 2018 at "Molecules"
DOI: 10.3390/molecules23113036
Abstract: Human immunodeficiency virus type 1 (HIV-1) is responsible for the majority of HIV infections worldwide, and we still lack a cure for this infection. Blocking the interaction of HIV-1 and its primary receptor CD4 is… read more here.
Keywords: entry inhibitors; primary receptor; hiv entry; via cd4 ... See more keywords
Structure-Based Identification of Natural-Product-Derived Compounds with Potential to Inhibit HIV-1 Entry
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020474
Abstract: Broadly neutralizing antibodies (bNAbs) are potent in neutralizing a wide range of HIV strains. VRC01 is a CD4-binding-site (CD4-bs) class of bNAbs that binds to the conserved CD4-binding region of HIV-1 envelope (env) protein. Natural… read more here.
Keywords: hiv; entry; hiv entry; clade ... See more keywords
A Novel CXCR4 Targeting Protein SDF-1/54 as an HIV-1 Entry Inhibitor
Sign Up to like & getrecommendations! Published in 2019 at "Viruses"
DOI: 10.3390/v11090874
Abstract: CXC chemokine receptor 4 (CXCR4) is a co-receptor for HIV-1 entry into target cells. Its natural ligand, the chemokine SDF-1, inhibits viral entry mediated by this receptor. However, the broad expression pattern of CXCR4 and… read more here.
Keywords: hiv entry; hiv; entry inhibitor; sdf ... See more keywords