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1
Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.10.015
Abstract: &NA; The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human diseases, such as cancer. CXCR4 is also a major co‐receptor facilitating HIV entry. Accordingly, CXCR4 is considered as an attractive…
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Keywords:
hiv entry;
cxcr4 targeting;
activity;
targeting nanobodies ... See more keywords
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Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2017.08.030
Abstract: Bowman-Birk inhibitor (BBI) is a soybean-derived protease inhibitor that has anti-inflammation and anti-HIV effect. Here, we further investigated the anti-HIV action of BBI in macrophages, focusing on its effect on viral entry. We found that…
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Keywords:
birk inhibitor;
hiv entry;
bowman birk;
entry ... See more keywords
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1
Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00444
Abstract: A bivalent compound 1a featuring both a mu opioid receptor (MOR) and a CXCR4 antagonist pharmacophore (naltrexone and IT1t) was designed and synthesized. Further binding and functional studies demonstrated 1a acting as a MOR and…
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Keywords:
cxcr4;
mor cxcr4;
bivalent ligand;
receptor ... See more keywords
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2
Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.916487
Abstract: Given the high variability and drug-resistance problem by human immunodeficiency virus type 1 (HIV-1), the development of bispecific or multi-specific inhibitors targeting different steps of HIV entry is highly appreciated. We previously generated a very…
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Keywords:
cell;
fusion;
hiv;
hiv entry ... See more keywords
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1
Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18071575
Abstract: Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people…
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Keywords:
5p12 rantes;
hiv entry;
cyclization;
terminal cyclization ... See more keywords
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Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22095052
Abstract: Cassia abbreviata is widely used in Sub-Saharan Africa for treating many diseases, including HIV-1 infection. We have recently described the chemical structures of 28 compounds isolated from an alcoholic crude extract of barks and roots…
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Keywords:
cassia abbreviata;
hiv entry;
infection;
entry ... See more keywords
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1
Published in 2018 at "Molecules"
DOI: 10.3390/molecules23113036
Abstract: Human immunodeficiency virus type 1 (HIV-1) is responsible for the majority of HIV infections worldwide, and we still lack a cure for this infection. Blocking the interaction of HIV-1 and its primary receptor CD4 is…
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Keywords:
entry inhibitors;
primary receptor;
hiv entry;
via cd4 ... See more keywords
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Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020474
Abstract: Broadly neutralizing antibodies (bNAbs) are potent in neutralizing a wide range of HIV strains. VRC01 is a CD4-binding-site (CD4-bs) class of bNAbs that binds to the conserved CD4-binding region of HIV-1 envelope (env) protein. Natural…
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Keywords:
hiv;
entry;
hiv entry;
clade ... See more keywords
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1
Published in 2019 at "Viruses"
DOI: 10.3390/v11090874
Abstract: CXC chemokine receptor 4 (CXCR4) is a co-receptor for HIV-1 entry into target cells. Its natural ligand, the chemokine SDF-1, inhibits viral entry mediated by this receptor. However, the broad expression pattern of CXCR4 and…
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Keywords:
hiv entry;
hiv;
entry inhibitor;
sdf ... See more keywords