Modulation of the NF-κB signaling pathway by the HIV-2 envelope glycoprotein and its incomplete BST-2 antagonism.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2017.09.024
Abstract: The HIVs have evolved by selecting means to hijack numerous host cellular factors. HIVs exploit the transcription factor NF-κB to ensure efficient LTR-driven gene transcription. However, NF-κB is primarily known to act as a key… read more here.
Keywords: hiv env; pathway hiv; signaling pathway; bst ... See more keywords
Targeting cell surface HIV-1 Env protein to suppress infectious virus formation.
Sign Up to like & getrecommendations! Published in 2017 at "Virus research"
DOI: 10.1016/j.virusres.2017.04.003
Abstract: HIV-1 Env protein is essential for host cell entry, and targeting Env remains an important antiretroviral strategy. We previously found that a peptide triazole thiol KR13 and its gold nanoparticle conjugate AuNP-KR13 directly and irreversibly… read more here.
Keywords: env protein; cell; virus; hiv env ... See more keywords
Conformational Changes in HIV-1 Env Trimer Induced by a Single CD4 as Revealed by Cryo-EM
Sign Up to like & getrecommendations! Published in 2017 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927617006614
Abstract: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA Laboratory of… read more here.
Keywords: env trimer; hiv env; microscopy; conformational changes ... See more keywords
Structure dynamics of HIV-1 Env trimers on native virions engaged with living T cells
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02658-1
Abstract: The HIV-1 envelope glycoprotein (Env) mediates viral entry into the host cell. Although the highly dynamic nature of Env intramolecular conformations has been shown with single molecule spectroscopy in vitro, the bona fide Env intra-… read more here.
Keywords: hiv env; native virions; intramolecular conformations; living cells ... See more keywords
Corrigendum: HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/srep46991
Abstract: This corrects the article DOI: 10.1038/srep40037. read more here.
Keywords: corrigendum hiv; env associates; hiv env; associates hla ... See more keywords
Genetic analyses of HIV env associated with uveitis in antiretroviral-naive individuals
Sign Up to like & getrecommendations! Published in 2017 at "AIDS"
DOI: 10.1097/qad.0000000000001550
Abstract: Objective: To analyze and compare HIV-1 env sequences from the eye to those from the blood of individuals with uveitis attributed to HIV with the goal of gaining insight into the pathogenesis of HIV-associated eye… read more here.
Keywords: naive individuals; hiv env; aqueous humor; humor ... See more keywords
Production of HIV-1 Env-Specific Antibodies Mediating Innate Immune Functions Depends on Cognate Interleukin-21- Secreting CD4+ T Cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.02097-20
Abstract: To develop a vaccine or immunotherapy that would cure the HIV-1 infection, it is important to identify helper T cells able to mount an efficient antibody response. Here, we demonstrate that the generation of HIV-1… read more here.
Keywords: env specific; innate; hiv; specific antibodies ... See more keywords
The HIV Env Glycoprotein Conformational States on Cells and Viruses
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DOI: 10.1128/mbio.01825-21
Abstract: The HIV Env glycoprotein is the surface glycoprotein responsible for viral entry into CD4+ immune cells. During infection, Env also serves as a primary target for antibody responses, which are robust but unable to control… read more here.
Keywords: env glycoprotein; cell; conformational states; env ... See more keywords
A single gp120 residue can affect HIV-1 tropism in macaques
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1006572
Abstract: Species-dependent variation in proteins that aid or limit virus replication determines the ability of lentiviruses to jump between host species. Identifying and overcoming these differences facilitates the development of animal models for HIV-1, including models… read more here.
Keywords: gp120 residue; hiv env; affect hiv; hiv ... See more keywords
The Characteristics of the HIV-1 Env Glycoprotein Are Linked With Viral Pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.763039
Abstract: The understanding of HIV-1 pathogenesis and clinical progression is incomplete due to the variable contribution of host, immune, and viral factors. The involvement of viral factors has been investigated in extreme clinical phenotypes from rapid… read more here.
Keywords: envs; glycoprotein; progressor; characteristics hiv ... See more keywords