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   Articles with "hiv envelope" as a keyword



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Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform.

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recommendations! Published in 2017 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-6869-5_14

Abstract: The generation of a strong antibody response to target antigens is a major goal for vaccine development. Here we describe the display of the human immunodeficiency virus (HIV) envelope spike protein (Env) on a virus-like… read more here.

Keywords: phage; hiv envelope; display; vaccine platform ... See more keywords
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Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model

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recommendations! Published in 2017 at "Cell Reports"

DOI: 10.1016/j.celrep.2017.09.024

Abstract: Summary Recent efforts toward HIV vaccine development include the design of immunogens that can engage B cell receptors with the potential to affinity mature into broadly neutralizing antibodies (bnAbs). V2-apex bnAbs, which bind a protein-glycan… read more here.

Keywords: hiv; hiv envelope; neutralizing antibodies; wild type ... See more keywords
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HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

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recommendations! Published in 2020 at "Cell Reports"

DOI: 10.1016/j.celrep.2020.107583

Abstract: Summary Structural and functional studies of HIV envelope glycoprotein (Env) as a transmembrane protein have long been complicated by challenges associated with inherent flexibility of the molecule and the membrane-embedded hydrophobic regions. Here, we present… read more here.

Keywords: antibody structures; mper antibody; antibody; hiv envelope ... See more keywords
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Impact of HIV-1 Envelope Conformation on ADCC Responses.

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recommendations! Published in 2018 at "Trends in microbiology"

DOI: 10.1016/j.tim.2017.10.007

Abstract: HIV-1 envelope glycoproteins (Env) represent the only virus-specific antigen exposed at the surface of infected cells. In its unliganded form, Env from primary viruses samples a 'closed' conformation (State 1), which is preferentially recognized by… read more here.

Keywords: adcc; conformation; adcc responses; hiv envelope ... See more keywords
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Protein and glycan molecular weight determination of highly glycosylated HIV-1 envelope trimers by HPSEC-MALS.

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recommendations! Published in 2021 at "Vaccine"

DOI: 10.1016/j.vaccine.2021.05.048

Abstract: High Performance Size-Exclusion Chromatography coupled with Multi-Angle Light Scattering detection (HPSEC-MALS) is an important tool to provide a reliable molecular weight measurement for a large complex biomolecule. A recent HIV-1 soluble envelope trimer vaccine candidate,… read more here.

Keywords: weight; glycan molecular; hiv envelope; molecular weight ... See more keywords
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Conformation of the native HIV-1 envelope protein raises questions for vaccine design

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recommendations! Published in 2019 at "Nature"

DOI: 10.1038/d41586-019-01085-x

Abstract: The HIV-1 envelope protein is the target of antibodies that neutralize the virus. A fresh look into the conformational states of this protein relaunches the quest to identify those relevant for vaccine design.Relevance of HIV-1… read more here.

Keywords: protein; vaccine design; hiv; hiv envelope ... See more keywords
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Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

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recommendations! Published in 2021 at "NPJ Vaccines"

DOI: 10.1038/s41541-021-00364-x

Abstract: The immunogenicity of HIV-1 envelope (Env) trimers is generally poor. We used the clinically relevant ConM SOSIP trimer to compare the ability of different adjuvants (squalene emulsion, ISCOMATRIX, GLA-LSQ, and MPLA liposomes) to support neutralizing… read more here.

Keywords: gla lsq; adjuvants nanoparticle; hiv envelope; presentation ... See more keywords
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Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

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recommendations! Published in 2019 at "Nature"

DOI: 10.1038/s41586-019-1101-y

Abstract: The HIV-1 envelope glycoprotein (Env) trimer mediates cell entry and is conformationally dynamic1–8. Imaging by single-molecule fluorescence resonance energy transfer (smFRET) has revealed that, on the surface of intact virions, mature pre-fusion Env transitions from… read more here.

Keywords: state; envelope glycoprotein; hiv; hiv envelope ... See more keywords
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Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a Glycan

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-33390-2

Abstract: The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune response and a critical vaccine candidate. However, Env is densely glycosylated and thereby substantially protected from neutralisation. Importantly, glycan N301 shields V3… read more here.

Keywords: structural rearrangements; hiv envelope; rearrangements maintain; glycan shield ... See more keywords
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Development of a synthetic nanoparticle vaccine presenting the HIV-1 envelope glycoprotein

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recommendations! Published in 2022 at "Nanotechnology"

DOI: 10.1088/1361-6528/ac842c

Abstract: Two-component self-assembling virus-like particles (VLPs) are promising scaffolds for achieving high-density display of HIV-1 envelope (gp140) trimers, which can improve the induction of neutralising antibodies (NAbs). In this study gp140 was displayed on the surface… read more here.

Keywords: nanoparticle; gp140; coupled vlps; hiv envelope ... See more keywords
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Cross-neutralizing CRF01_AE-infected Plasma from Malaysia Targets CD4-binding Site of Human Immunodeficiency Virus Type-1 (HIV-1) Envelope Glycoprotein.

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recommendations! Published in 2021 at "AIDS research and human retroviruses"

DOI: 10.1089/aid.2020.0299

Abstract: HIV-1 antigenic variation poses a great challenge for vaccine immunogen design to elicit broadly neutralizing antibodies (bNAb). Over the last 10-15 years great progress has been made to understand the conserved sites of sensitivity on… read more here.

Keywords: hiv envelope; crf01 infected; hiv; cross ... See more keywords