Efficient treatment and pre-exposure prophylaxis in rhesus macaques by an HIV fusion-inhibitory lipopeptide
Sign Up to like & getrecommendations! Published in 2022 at "Cell"
DOI: 10.1016/j.cell.2021.11.032
Abstract: Two HIV fusion-inhibitory lipopeptides (LP-97 and LP-98) were designed with highly potent, long-acting antiviral activity. Monotherapy using a low dose of LP-98 sharply reduced viral loads and maintained long-term viral suppression in 21 SHIVSF162P3-infected rhesus… read more here.
Keywords: pre exposure; rhesus macaques; exposure prophylaxis; fusion inhibitory ... See more keywords
Design, Characterization, and Biopharmaceutical Behavior of Nanoparticles Loaded with an HIV-1 Fusion Inhibitor Peptide.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00609
Abstract: New therapeutic alternatives to fight against the spread of HIV-1 are based on peptides designed to inhibit the early steps of HIV-1 fusion in target cells. However, drawbacks, such as bioavailability, short half-life, rapid clearance,… read more here.
Keywords: inhibitor peptide; hiv fusion; fusion inhibitor; fusion ... See more keywords
Inhibition of HIV Fusion by Small Molecule Agonists through Efficacy-Engineering of CXCR4.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00061
Abstract: CXC chemokine receptor 4 (CXCR4) is involved in multiple physiological and pathological processes, notably as a coreceptor for human immunodeficiency virus (HIV) cell entry. Its broad expression pattern and vital biological importance make CXCR4 a… read more here.
Keywords: hiv fusion; engineering; small molecule; hiv ... See more keywords
P848 Revisiting enfuvirtide’s mechanism and designing its analog with improved activity by targeting triple sites in gp41
Sign Up to like & getrecommendations! Published in 2019 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2019-sti.891
Abstract: Background In the early of 1990’s, several peptides overlapping gp41 CHR region, including SJ-2176, T20, and C34 were reported to have potent HIV-1 fusion inhibitory activity. T20 (generic name: enfuvirtide) was approved by the U.S.… read more here.
Keywords: t20; hiv fusion; mechanism; fusion ... See more keywords
Conformational Stabilization of Gp41-Mimetic Miniproteins Opens Up New Ways of Inhibiting HIV-1 Fusion
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052794
Abstract: Inhibition of the HIV-1 fusion process constitutes a promising strategy to neutralize the virus at an early stage before it enters the cell. In this process, the envelope glycoprotein (Env) plays a central role by… read more here.
Keywords: gp41; fusion; chr region; inhibitory activity ... See more keywords
A Protein-Based, Long-Acting HIV-1 Fusion Inhibitor with an Improved Pharmacokinetic Profile
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15040424
Abstract: Recently, a series of highly effective peptide- or protein-based HIV fusion inhibitors have been identified. However, due to their short half-life, their clinical application is limited. Therefore, the development of long-acting HIV fusion inhibitors is… read more here.
Keywords: fusion inhibitor; fusion; hiv fusion; protein based ... See more keywords