Induction of a high-titered antibody response using HIV gag-EV71 VP1-based virus-like particles with the capacity to protect newborn mice challenged with a lethal dose of enterovirus 71
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3797-7
Abstract: Enterovirus 71 (EV71) is the most frequently detected causative agent in hand, foot, and mouth disease (HFMD) and is a serious threat to public health in the Asia-Pacific region. Many EV71 vaccines are under development worldwide,… read more here.
Keywords: ev71 vp1; virus like; gag; vp1 ... See more keywords
Construction, Selection and Immunogenicity of Recombinant Fowlpox Candidate Vaccine Co-expressing HIV-1 gag and gp145
Sign Up to like & getrecommendations! Published in 2017 at "Indian Journal of Microbiology"
DOI: 10.1007/s12088-017-0639-3
Abstract: An HIV candidate vaccine for the Chinese population was designed by constructing a recombinant fowlpox virus expressing HIV-1 gag and HIV gp145 proteins via homologous recombination and plaque screening using enhanced green fluorescent protein (EGFP)… read more here.
Keywords: recombinant fowlpox; candidate vaccine; expressing hiv; hiv gag ... See more keywords
Genomic RNA Binding Promotes Retroviral Gag Protein Interactions in an Assembly-Competent Conformation Leading to Selective Genome Packaging
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1699
Abstract: In HIV-1 infected cells, full-length viral genomic RNA (gRNA) is selectively packaged by the HIV-1 Gag protein despite a vast excess of spliced viral and host RNAs. The mechanism of this selective packaging is incompletely… read more here.
Keywords: psi rna; gag; rna; genomic rna ... See more keywords
High frequency of CD8 escape mutations in elite controllers as new obstacle for HIV cure
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2129353
Abstract: ABSTRACT Accumulation of mutations in epitopes of cytolytic-T-lymphocytes immune response (CTL) in HIV-reservoir seems to be one of the reasons for shock-and-kill strategy failure. Ten non-controller patients on successful cART (TX) and seven elite controllers… read more here.
Keywords: elite controllers; hiv; escape mutations; hiv gag ... See more keywords
Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz202
Abstract: Abstract A hallmark of translation in human immunodeficiency virus type 1 (HIV-1) is a –1 programmed ribosome frameshifting event that produces the Gag-Pol fusion polyprotein. The constant Gag to Gag-Pol ratio is essential for the… read more here.
Keywords: modulation hiv; gag; hiv gag; gag gag ... See more keywords
Specific inter-domain interactions stabilize a compact HIV-1 Gag conformation
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0221256
Abstract: HIV-1 Gag is a large multidomain poly-protein with flexible unstructured linkers connecting its globular subdomains. It is compact when in solution but assumes an extended conformation when assembled within the immature HIV-1 virion. Here, we… read more here.
Keywords: gag; hiv gag; cactd; domain interactions ... See more keywords
Recent Advances in HIV-1 Gag Inhibitor Design and Development
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25071687
Abstract: Acquired Immune Deficiency Syndrome (AIDS) treatment with combination antiretroviral therapy (cART) has improved the life quality of many patients since its implementation. However, resistance mutations and the accumulation of severe side effects associated with cART… read more here.
Keywords: inhibitor design; hiv gag; recent advances; design ... See more keywords
Identification of New L-Heptanoylphosphatidyl Inositol Pentakisphosphate Derivatives Targeting the Interaction with HIV-1 Gag by Molecular Modelling Studies
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15101255
Abstract: The HIV-1 Gag protein binds to the host cell membrane and assembles into immature particles. Then, in the course of immature virion budding, activated protease cleaves Gag into its main components: MA, CA, NC, and… read more here.
Keywords: heptanoylphosphatidyl inositol; hiv gag; inositol pentakisphosphate;
Distinct Contributions of Different Domains within the HIV-1 Gag Polyprotein to Specific and Nonspecific Interactions with RNA
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12040394
Abstract: Viral genomic RNA is packaged into virions with high specificity and selectivity. However, in vitro the Gag specificity towards viral RNA is obscured when measured in buffers containing physiological salt. Interestingly, when the binding is… read more here.
Keywords: gag; rna; distinct contributions; hiv gag ... See more keywords
No Difference in the Prevalence of HIV-1 gag Cytotoxic T-Lymphocyte-Associated Escape Mutations in Viral Sequences from Early and Late Parts of the HIV-1 Subtype C Pandemic in Botswana
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11051000
Abstract: HIV is known to accumulate escape mutations in the gag gene in response to the immune response from cytotoxic T lymphocytes (CTLs). These mutations can occur within an individual as well as at a population… read more here.
Keywords: time; hiv; escape mutations; prevalence ... See more keywords
Conserved broad HIV-1 Gag-specific responses associated with low viral load and high CD4+ T cell nadir and preserved HAART regimen.
Sign Up to like & getrecommendations! Published in 2021 at "Acta virologica"
DOI: 10.4149/av_2021_311
Abstract: Broad human immunodeficiency virus type 1 (HIV-1) Gag-specific cellular responses can control viremia and provide slow progression to Acquired immunodeficiency syndrome (AIDS). In this study, we evaluate multiple HIV-1 Gag-specific lymphoproliferative responses and find their… read more here.
Keywords: gag specific; gag; viral load; hiv gag ... See more keywords