Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling
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DOI: 10.1038/s41598-018-19298-x
Abstract: The capacity of HIV-1 to develop resistance to current drugs calls for innovative strategies to control this infection. We aimed at developing novel inhibitors of HIV-1 replication by targeting viral RNA processing—a stage dependent on… read more here.
Keywords: mek1 erk1; gene expression; hiv gene;
Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation
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DOI: 10.1186/s12977-019-0478-x
Abstract: BackgroundThe human immunodeficiency virus (HIV) cell reservoir is currently a main obstacle towards complete eradication of the virus. This infected pool is refractory to anti-viral therapy and harbors integrated proviruses that are transcriptionally repressed but… read more here.
Keywords: transcription; latency; gene transcription; hiv gene ... See more keywords
[HIV-1 gene subtypes among newly reported HIV/AIDS cases in two border areas of Yunnan province].
Sign Up to like & getrecommendations! Published in 2018 at "Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi"
DOI: 10.3760/cma.j.issn.0254-6450.2018.12.015
Abstract: Objective: To explore the features of distribution on HIV-1 gene subtypes among newly reported HIV/AIDS cases in the border areas of Yunnan province. Methods: A total of 233 newly reported HIV/AIDS cases aged 18 or… read more here.
Keywords: hiv aids; gene subtypes; prefecture; hiv gene ... See more keywords
Human transcription factor YY1 could upregulate the HIV-1 gene expression
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DOI: 10.5483/bmbrep.2020.53.5.222
Abstract: Gene expression in HIV-1 is regulated by the promoters in 5’ long-terminal repeat (LTR) element, which contain multiple DNA regulatory elements that serve as binding sites for cellular transcription factors. YY1 could repress HIV-1 gene… read more here.
Keywords: expression; yy1 could; gene expression; hiv gene ... See more keywords