HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01104
Abstract: HIV-1 infection is typically treated using ≥2 drugs, including at least one HIV-1 reverse transcriptase (RT) inhibitor. Drugs targeting RT comprise nucleos(t)ide RT inhibitors (NRTIs) and non-nucleoside RT inhibitors (NNRTIs). NRTI-triphosphates bind at the polymerase… read more here.
Keywords: reverse transcriptase; hiv gp120; hiv reverse;
Mutation in the D1 domain of CD4 receptor modulates the binding affinity to HIV-1 gp120
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra06628a
Abstract: The gp120 surface subunit of HIV-1 envelope lycoprotein (Env) is the key component for the viral entry process through interaction with the CD4 binding site (CD4bs) of the primary receptor CD4. The point mutant was… read more here.
Keywords: cd4 receptor; gp120; hiv gp120; cd4 ... See more keywords
Study on molecular mechanisms of CD4 dependency and independency of HIV-1 gp120
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00433c
Abstract: Different HIV-1 strains have different antibody neutralization phenotypes (or CD4-dependencies). However, the molecular mechanisms underlying these differences remain to be elucidated. In this study, we constructed gp120 structural models from the CD4-dependent, neutralization-resistant JR-FL strain… read more here.
Keywords: hiv; study molecular; molecular mechanisms; gp120 ... See more keywords
HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.811481
Abstract: HIV-associated neurocognitive disorders (HAND) remain an unsolved problem that persists despite using antiretroviral therapy. We have obtained data showing that HIV-gp120 protein contributes to neurodegeneration through metabolic reprogramming. This led to decreased ATP levels, lower… read more here.
Keywords: cyclic amp; amp response; gp120; hiv gp120 ... See more keywords
Behavioral Evidence for a Tau and HIV-gp120 Interaction
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105514
Abstract: Despite successful virologic control with combination antiretroviral therapy (cART), about half of people living with the human immunodeficiency virus-1 (HIV) develop an HIV-associated neurocognitive disorder (HAND). It is estimated that 50% of individuals who are… read more here.
Keywords: interaction; hiv; tau; evidence ... See more keywords
CXCR4 Recognition by L- and D-Peptides Containing the Full-Length V3 Loop of HIV-1 gp120
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15051084
Abstract: Human immunodeficiency virus-1 (HIV-1) recognizes one of its principal coreceptors, CXC chemokine receptor 4 (CXCR4), on the host cell via the third variable loop (V3 loop) of HIV-1 envelope glycoprotein gp120 during the viral entry… read more here.
Keywords: recognition; loop; hiv; cxcr4 ... See more keywords