Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2)
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2017.1262349
Abstract: ABSTRACT Diaryltriazine derivatives, which are structurally related to diarylpyrimidines, are a representative class of HIV-1 reverse transcriptase inhibitors with remarkable antiviral activities against wild-type and several mutant strains of HIV-1. A series of novel diaryltriazines… read more here.
Keywords: potent hiv; novel diaryltriazines; hiv; hiv inhibitors ... See more keywords
A Novel Class of HIV-1 Inhibitors Targeting the Vpr-Induced G2-Arrest in Macrophages by New Yeast- and Cell-Based High-Throughput Screening
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14061321
Abstract: The human immunodeficiency virus type 1 (HIV-1) accessory protein, Vpr, arrests the cell cycle of the G2 phase, and this Vpr-mediated G2 arrest is implicated in an efficient HIV-1 spread in monocyte-derived macrophages. Here, we… read more here.
Keywords: cell based; hiv; yeast; hiv inhibitors ... See more keywords