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Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.08.004
Abstract: The persistence of a pool of latently HIV-1-infected cells despite combination anti-retroviral therapy treatment is the major roadblock for a cure. The BAF (mammalian SWI/SNF) chromatin remodeling complex is involved in establishing and maintaining viral…
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Keywords:
hiv latency;
latency;
specific baf;
latency reversal ... See more keywords
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Published in 2017 at "Trends in immunology"
DOI: 10.1016/j.it.2016.12.003
Abstract: Combinatory antiretroviral therapy (cART) increases the survival and quality of life of HIV-1-infected patients. However, interruption of therapy almost invariably leads to the re-emergence of detectable viral replication because HIV-1 persists in viral latent reservoirs.…
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Keywords:
hiv latency;
latency shock;
hiv;
shock lock ... See more keywords
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Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.06.019
Abstract: Development of a cure for HIV/AIDS has been a great challenge due to the establishment of the HIV-1 viral reservoir, mainly within resting CD4+ memory T cells. As a step towards a cure for HIV,…
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Keywords:
system;
drug;
reactivation;
hiv latency ... See more keywords
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Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00339
Abstract: Currently, due to the HIV latency mechanism, the search continues for effective drugs to combat this issue and provide a cure for AIDS. Gnidimacrin activates latent HIV-1 replication and inhibits HIV-1 infection at picomolar concentrations.…
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Keywords:
latency;
gnidimacrin derivatives;
activity relationship;
structure activity ... See more keywords
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Published in 2021 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.0c01039
Abstract: The discovery of efficient and specific HIV-latency-reversing agents is critical for HIV therapy. Here, we developed wikstroelide E, a daphnane diterpene from the buds of Wikstroemia chamaedaphne, as a potential HIV-latency-reversing agent that is 2500-fold…
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Keywords:
potential hiv;
hiv;
latency reversing;
hiv latency ... See more keywords
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Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00151
Abstract: The total synthesis and biological evaluation of the marine sesterterpenoid ansellone A (1), an HIV latency-reversing agent, and its analogues are reported. The key to the success of this synthetic route is a Prins cyclization…
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Keywords:
biological evaluation;
total synthesis;
latency reversing;
hiv latency ... See more keywords
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Published in 2020 at "Nature microbiology"
DOI: 10.1038/s41564-020-0742-9
Abstract: Quiescence is a hallmark of CD4 + T cells latently infected with human immunodeficiency virus 1 (HIV-1). While reversing this quiescence is an effective approach to reactivate latent HIV from T cells in culture, it…
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Keywords:
quiescence;
hiv;
foxo1 promotes;
stress ... See more keywords
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Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1803468115
Abstract: Significance The molecular mechanisms leading to the creation and maintenance of the latent HIV reservoir remain incompletely understood. Unbiased shRNA screens showed that the estrogen receptor acts as a potent repressor of proviral reactivation in…
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Keywords:
receptor;
hiv latency;
hiv;
estrogen receptor ... See more keywords
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Published in 2022 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2021.0195
Abstract: HIV remains incurable due to the persistence of a latent viral reservoir found in HIV infected cells, primarily resting memory CD4+ T cells. Depletion of this reservoir may be the only way to end this…
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Keywords:
histone;
latency reversal;
hdac inhibitors;
latency ... See more keywords
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Published in 2022 at "PLOS Pathogens"
DOI: 10.1101/2022.08.23.504195
Abstract: Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1. We developed a new latency CRISPR screening strategy, called Latency HIV-CRISPR, which uses…
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Keywords:
hiv;
crispr;
screen;
combination ... See more keywords
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Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav6322
Abstract: Targeted nanocarriers deliver HIV-1 latency-reversing agents to CD4+ T cells in the lymph nodes. A proposed strategy to cure HIV uses latency-reversing agents (LRAs) to reactivate latent proviruses for purging HIV reservoirs. A variety of…
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Keywords:
cd4 cells;
latency;
hiv;
hybrid nanocarriers ... See more keywords