Small heat shock protein 27: An effective adjuvant for enhancement of HIV-1 Nef antigen-specific immunity.
Sign Up to like & getrecommendations! Published in 2017 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.09.005
Abstract: Novel vaccine modalities have been designed to improve the efficiency of vaccines against HIV infections. In this way, the HIV-1 Nef protein has been known as an attractive antigenic candidate in therapeutic vaccine development. Moreover,… read more here.
Keywords: protein; hiv nef; heat shock;
HIV‐1 Nef‐POTEE; A novel interaction modulates macrophage dissemination via mTORC2 signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.10.068
Abstract: Aims: Human immunodeficiency virus −1 [HIV‐1] Nef, localizes in different cellular compartments and modulates several cellular pathways. Nef promotes virus pathogenicity through alteration in cell surface receptor expression, apoptosis, protein trafficking etc. Nef regulates viral… read more here.
Keywords: cell; potee; nef potee; interaction ... See more keywords
Modulation of TCR-dependent NFAT signaling is impaired in HIV-1 Nef isolates from elite controllers.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.02.008
Abstract: HIV-1 Nef modulates the activation state of CD4+ T cells by altering signaling events elicited by the T cell receptor (TCR). Primary nef sequences exhibit extensive inter-individual diversity that influences their ability to downregulate CD4… read more here.
Keywords: hiv; nfat signaling; elite controllers; hiv nef ... See more keywords
Inhibitors of HIV-1 Nef-Mediated Activation of the Myeloid Src-Family Kinase Hck Block HIV-1 Replication in Macrophages and Disrupt MHC-I Downregulation.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00288
Abstract: HIV-1 Nef is an attractive target for antiretroviral drug discovery because of its role in promoting HIV-1 infectivity, replication, and host immune system avoidance. Here, we applied a screening strategy in which recombinant HIV-1 Nef… read more here.
Keywords: hiv; replication; hck; hiv nef ... See more keywords
HIV-I Nef inhibitors: a novel class of HIV-specific immune adjuvants in support of a cure
Sign Up to like & getrecommendations! Published in 2017 at "AIDS Research and Therapy"
DOI: 10.1186/s12981-017-0175-6
Abstract: The success of many current vaccines relies on a formulation that incorporates an immune activating adjuvant. This will hold true for the design of a successful therapeutic HIV vaccine targeted at controlling reactivated virus following… read more here.
Keywords: hiv; cure hiv; hiv nef; immune adjuvants ... See more keywords
In Vitro Delivery of HIV-1 Nef-Vpr DNA Construct Using the Human Antimicrobial Peptide LL-37.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug delivery"
DOI: 10.2174/1567201819666220217164055
Abstract: BACKGROUND AND OBJECTIVES DNA-based therapeutic vaccines have been proposed as promising strategy for treatment of established HIV infections. However, these vaccines are often associated with certain shortcomings, such as poor immunogenicity and low transfection efficiency.… read more here.
Keywords: dna; delivery; nef vpr; hiv nef ... See more keywords
Novel role of HIV-1 Nef in regulating the ubiquitination of cellular proteins
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1106591
Abstract: Our recent data established that HIV-1 Nef is pivotal in determining the fate of cellular proteins by modulating ubiquitination. However, it is unknown which proteins are ubiquitinated in the presence of Nef, a question critical… read more here.
Keywords: novel role; hiv nef; analysis; cellular proteins ... See more keywords