HIV-1 Sequence Necessary and Sufficient to Package Non-viral RNAs into HIV-1 Particles.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.06.018
Abstract: Genome packaging is an essential step to generate infectious HIV-1 virions and is mediated by interactions between the viral protein Gag and cis-acting elements in the full-length RNA. The sequence necessary and sufficient to allow… read more here.
Keywords: non viral; rna; hiv particles; packaging ... See more keywords
Release of HIV-1 particles from macrophages is promoted by an anchored cytoskeleton and driven by mechanical constraints.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.260511
Abstract: A feature of HIV-1 replication in macrophages is that viral assembly occurs at the limiting membrane of a compartment often named VCC (virus-containing compartments). Assembled virions accumulate in the lumen of the VCC, from where… read more here.
Keywords: actin cytoskeleton; release hiv; hiv particles; particles macrophages ... See more keywords
Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010754
Abstract: In infectious HIV-1 particles, the capsid protein (CA) forms a cone-shaped shell called the capsid, which encases the viral ribonucleoprotein complex (vRNP). Following cellular entry, the capsid is disassembled through a poorly understood process referred… read more here.
Keywords: functions native; localization functions; hiv particles; native egfp ... See more keywords
Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53
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DOI: 10.7554/elife.67321
Abstract: During HIV-1 particle formation, the requisite plasma membrane curvature is thought to be solely driven by the retroviral Gag protein. Here, we reveal that the cellular I-BAR protein IRSp53 is required for the progression of… read more here.
Keywords: irsp53; hiv particles; membrane curvature; membrane ... See more keywords