High-throughput sequencing identifies HIV-1-replication- and latency-related miRNAs in CD4+ T cell lines
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Virology"
DOI: 10.1007/s00705-017-3305-5
Abstract: MicroRNAs are potent gene expression regulators involved in regulating various biological processes, including host-pathogen interactions. In this study, we used high-throughput sequencing to investigate cellular miRNA signatures related to HIV-1 replication and latent infection in… read more here.
Keywords: hiv replication; throughput sequencing; infection; cell ... See more keywords
Inhibition of NF‐&kgr;B‐dependent HIV‐1 replication by the marine natural product bengamide A
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.02.017
Abstract: ABSTRACT HIV‐1 inhibitors that act by mechanisms distinct from existing antiretrovirals can provide novel insights into viral replication and potentially inform development of new therapeutics. Using a multi‐cycle HIV‐1 replication assay, we screened 252 pure… read more here.
Keywords: hiv replication; marine natural; hiv; expression ... See more keywords
HIV-1 replication benefits from the RNA epitranscriptomic code.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.09.021
Abstract: The effects of RNA methylation on HIV-1 replication remain largely unknown. Recent studies have discovered new insights into the effect of 2'-O-methylation and methylcytidine marks on the HIV-1 RNA genome. As so far, HIV-1 benefits… read more here.
Keywords: hiv replication; hiv; benefits rna; rna epitranscriptomic ... See more keywords
Inhibitors of HIV-1 Nef-Mediated Activation of the Myeloid Src-Family Kinase Hck Block HIV-1 Replication in Macrophages and Disrupt MHC-I Downregulation.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00288
Abstract: HIV-1 Nef is an attractive target for antiretroviral drug discovery because of its role in promoting HIV-1 infectivity, replication, and host immune system avoidance. Here, we applied a screening strategy in which recombinant HIV-1 Nef… read more here.
Keywords: hiv; replication; hck; hiv nef ... See more keywords
Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-70170-3
Abstract: Human immunodeficiency virus 1 (HIV-1) is a life-threatening pathogen that still lacks a curative therapy or vaccine. Despite the reduction in AIDS-related deaths achieved by current antiretroviral therapies, drawbacks including drug resistance and the failure… read more here.
Keywords: rev erb; hiv replication; replication; activity ... See more keywords
Hypoxic microenvironment shapes HIV-1 replication and latency
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-1103-1
Abstract: Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus (HIV) infected cells within secondary… read more here.
Keywords: hiv replication; replication; oxygen; replication latency ... See more keywords
S100A8 and S100A9, biomarkers of SARS-CoV-2-infection and other diseases, suppress HIV replication in primary macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2021.0193
Abstract: S100A8 and S100A9 are members of the Alarmin family; these proteins are abundantly expressed in neutrophils and form a heterodimer complex and secreted in plasma upon pathogen infection or acute inflammatory diseases. Recently, both proteins… read more here.
Keywords: s100a8 s100a9; infection; sars cov; cov infection ... See more keywords
Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab879
Abstract: Retroviral infection requires reverse transcription, and the reverse transcriptase (RT) uses cellular tRNA as its primer. In humans, the TRMT6-TRMT61A methyltransferase complex incorporates N1-methyladenosine modification at tRNA position 58 (m1A58); however, the role of m1A58… read more here.
Keywords: hiv replication; trna3lys; m1a58; steps hiv ... See more keywords
T-cell activation and B-cell interaction signatures in rectal tissues are associated with HIV replication in ex-vivo model of infection
Sign Up to like & getrecommendations! Published in 2022 at "AIDS"
DOI: 10.1097/qad.0000000000003356
Abstract: Objective: The rectal mucosa is a critical site of HIV vulnerability. We sought to identify transcriptomic features of rectal mucosal tissue prior to exposure associated with support or restriction of HIV replication. Design: Rectal tissue… read more here.
Keywords: cell; vivo; hiv; model infection ... See more keywords
Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication
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DOI: 10.1098/rsob.170115
Abstract: Viruses interact with multiple host cell factors. Some of these are required to promote viral propagation, others have roles in inhibiting infection. Here, we delineate the function of the cellular factor PHF13 (or SPOC1), a… read more here.
Keywords: integration; factor phf13; hiv replication; phf13 ... See more keywords
Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promotes HIV-1 Replication through Modulating microRNAs in Macrophages
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00053-23
Abstract: Viral reservoirs constitute an obstacle to curing HIV-1 diseases, despite antiretroviral therapy. Macrophages serve as viral reservoirs in HIV infection by promoting long-term replication and latency. ABSTRACT Macrophages can serve as a reservoir for human… read more here.
Keywords: hiv; replication; malat1; hiv infection ... See more keywords