Current strategies to induce selective killing of HIV‐1‐infected cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4mr0422-636r
Abstract: Although combination antiretroviral therapy (ART) has led to significant HIV‐1 suppression and improvement in immune function, persistent viral reservoirs remain that are refractory to intensified ART. ART poses many challenges such as adherence to drug… read more here.
Keywords: hiv; infected cells; current strategies; hiv infected ... See more keywords
The Alphabet Soup of HIV Reservoir Markers
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DOI: 10.1007/s11904-017-0355-y
Abstract: Purpose of ReviewDespite the success of antiretroviral therapy in suppressing HIV, life-long therapy is required to avoid HIV reactivation from long-lived viral reservoirs. Currently, there is intense interest in searching for therapeutic interventions that can… read more here.
Keywords: reservoir; viral reservoir; hiv; replication competent ... See more keywords
Tools for Visualizing HIV in Cure Research
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DOI: 10.1007/s11904-018-0376-1
Abstract: Purpose of ReviewThe long-lived HIV reservoir remains a major obstacle for an HIV cure. Current techniques to analyze this reservoir are generally population-based. We highlight recent developments in methods visualizing HIV, which offer a different,… read more here.
Keywords: visualizing hiv; hiv; hiv cure; hiv reservoir ... See more keywords
HIV-1 Reservoir Persistence and Decay: Implications for Cure Strategies
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DOI: 10.1007/s11904-022-00604-2
Abstract: Despite suppressive antiretroviral therapy (ART), a viral reservoir persists in individuals living with HIV that can reignite systemic replication should treatment be interrupted. Understanding how HIV-1 persists through effective ART is essential to develop cure… read more here.
Keywords: reservoir; persistence; cure strategies; hiv reservoir ... See more keywords
Improved assays to measure and characterize the inducible HIV reservoir
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DOI: 10.1016/j.ebiom.2018.09.036
Abstract: Background Improved assays are critical to better characterize the HIV reservoir and to reliably evaluate candidate intervention strategies. Here we describe different methods to quantify the HIV reservoir. Methods We developed an optimized quantitative viral… read more here.
Keywords: inducible rna; frequency; hiv; improved assays ... See more keywords
Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17898-8
Abstract: Clonal expansions occur in the persistent HIV reservoir as shown by the duplication of proviral integration sites. However, the source of the proliferation of HIV-infected cells remains unclear. Here, we analyze the TCR repertoire of… read more here.
Keywords: clonal expansions; reservoir; hiv; hiv reservoir ... See more keywords
Stable HIV Reservoir Despite Prolonged Low-Dose Mycophenolate to Limit CD4+ T-cell Proliferation
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac620
Abstract: Abstract Background The HIV reservoir of latently infected CD4+ T cells represents the barrier to cure. CD4+ T-cell proliferation is a mechanism that sustains the reservoir even during prolonged antiretroviral therapy (ART). Blocking proliferation may… read more here.
Keywords: hiv reservoir; cd4 cell; hiv; reservoir ... See more keywords
HIV reservoir: antiviral immune responses and immune interventions for curing HIV infection
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002479
Abstract: Abstract Antiretroviral therapy against human immunodeficiency virus (HIV) is effective in controlling viral replication but cannot completely eliminate HIV due to the persistence of the HIV reservoir. Innate and adaptive immune responses have been proposed… read more here.
Keywords: hiv; responses immune; immune responses; hiv reservoir ... See more keywords
Serum globulin levels are associated with HIV reservoir size and immune restoration during long‐term ART
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DOI: 10.1111/hiv.13393
Abstract: The objectives of this study were to analyze the relationship between serum globulin levels and immune restoration and HIV reservoir size during long‐term antiretroviral therapy (ART). read more here.
Keywords: hiv; immune restoration; serum globulin; hiv reservoir ... See more keywords
Applications and limitations of the passenger hypothesis for HIV reservoir persistence and cure
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DOI: 10.1128/jvi.00714-25
Abstract: ABSTRACT Antiretroviral therapy (ART) suppresses HIV replication in people living with HIV (PWH), but a persistent population of reservoir cells prevents cure. Reservoir cells are mostly anatomically dispersed, latently infected CD4+ T cells harboring one… read more here.
Keywords: replication; cure; hiv reservoir; reservoir cells ... See more keywords
Spatial technologies to evaluate the HIV-1 reservoir and its microenvironment in the lymph node
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DOI: 10.1128/mbio.01909-24
Abstract: ABSTRACT The presence of the HIV-1 reservoir, a group of immune cells that contain intact, integrated, and replication-competent proviruses, is a major challenge to cure HIV-1. HIV-1 reservoir cells are largely unaffected by the cytopathic… read more here.
Keywords: follicle; hiv reservoir; hiv; lymph node ... See more keywords