Polymorphisms of the cytidine deaminase APOBEC3F have different HIV-1 restriction efficiencies.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2018.11.004
Abstract: The APOBEC3 enzyme family are host restriction factors that induce mutagenesis of HIV-1 proviral genomes through the deamination of cytosine to form uracil in nascent single-stranded (-)DNA. HIV-1 suppresses APOBEC3 activity through the HIV-1 protein… read more here.
Keywords: restriction; apobec3f 108; hiv; vif ... See more keywords
APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction
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DOI: 10.1128/mcb.00356-18
Abstract: APOBEC enzymes are DNA cytosine deaminases that normally serve as virus restriction factors, but several members, including APOBEC3H, also contribute to cancer mutagenesis. Despite their importance in multiple fields, little is known about cellular processes… read more here.
Keywords: restriction; zipcode; hiv restriction; subcellular localization ... See more keywords
Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G
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DOI: 10.2210/pdb6p3z/pdb
Abstract: APOBEC3G, a member of the double-domain cytidine deaminase (CD) APOBEC, binds RNA to package into virions and restrict HIV-1 through deamination-dependent or deamination-independent inhibition. Mainly due to lack of a full-length double-domain APOBEC structure, it… read more here.
Keywords: hiv restriction; full length; restriction; domain ... See more keywords
Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor Functioning
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DOI: 10.3390/v13020320
Abstract: Human immunodeficiency virus-1 (HIV-1) persists as a global health concern, with an incidence rate of approximately 2 million, and estimated global prevalence of over 35 million. Combination antiretroviral treatment is highly effective, but HIV-1 patients… read more here.
Keywords: hiv; trim5; hiv restriction; human trim5 ... See more keywords