Clearance of HIV-1 or SIV reservoirs by promotion of apoptosis and inhibition of autophagy: Targeting intracellular molecules in cure-directed strategies.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.4mr0222-606
Abstract: The reservoirs of the HIV display cellular properties resembling long-lived immune memory cells that could be exploited for viral clearance. Our interest in developing a cure for HIV stems from the studies of immunologic memory… read more here.
Keywords: hiv siv; hiv; clearance hiv; siv reservoirs ... See more keywords
Adaptive NK cell responses in HIV/SIV infections: A roadmap to cell‐based therapeutics?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.mr0718-303r
Abstract: NK cells play a critical role in antiviral and antitumor responses. Although current NK cell immune therapies have focused primarily on cancer biology, many of these advances can be readily applied to target HIV/simian immunodeficiency… read more here.
Keywords: biology; hiv siv; siv infections; cell ... See more keywords
C-C Chemokine receptor-like 2 (CCRL2) acts as coreceptor for human immunodeficiency virus-2.
Sign Up to like & getrecommendations! Published in 2020 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa333
Abstract: INTRODUCTION Most of the typical chemokine receptors (CKRs) have been identified as coreceptors for a variety of human and simian immunodeficiency viruses (HIVs and SIVs). This study evaluated CCRL2 to examine if it was an… read more here.
Keywords: immunodeficiency; ccrl2; hiv siv; hiv ... See more keywords
A penalized regression approach to haplotype reconstruction of viral populations arising in early HIV/SIV infection
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx187
Abstract: Motivation: Next generation sequencing (NGS) has been increasingly applied to characterize viral evolution during HIV and SIV infections. In particular, NGS datasets sampled during the initial months of infection are characterized by relatively low levels… read more here.
Keywords: reconstruction; infection; hiv siv; haplotype reconstruction ... See more keywords
Human Immunodeficiency Virus and Simian Immunodeficiency Virus Maintain High Levels of Infectivity in the Complete Absence of Mucin-Type O-Glycosylation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01228-17
Abstract: ABSTRACT A highly conserved threonine near the C terminus of gp120 of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) was investigated for its contributions to envelope protein function and virion infectivity. When this… read more here.
Keywords: hiv siv; glycosylation; immunodeficiency virus; infectivity ... See more keywords
The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010245
Abstract: Activation of the NF-κB signaling pathway by Protein Kinase C (PKC) agonists is a potent mechanism for human immunodeficiency virus (HIV) latency disruption in vitro. However, significant toxicity risks and the lack of evidence supporting… read more here.
Keywords: protein kinase; hiv; gsk445a; transcription ... See more keywords
The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010723
Abstract: Despite the advent of effective antiretroviral therapy (ART), human immunodeficiency virus (HIV) continues to pose major challenges, with extensive pathogenesis during acute and chronic infection prior to ART initiation and continued persistence in a reservoir… read more here.
Keywords: cd4 cells; role; cd4; hiv siv ... See more keywords