HIV-Specific B Cell Frequency Correlates with Neutralization Breadth in Patients Naturally Controlling HIV-Infection
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DOI: 10.1016/j.ebiom.2017.05.029
Abstract: HIV-specific broadly neutralizing antibodies (bnAbs) have been isolated from patients with high viremia but also from HIV controllers that repress HIV-1 replication. In these elite controllers (ECs), multiple parameters contribute to viral suppression, including genetic… read more here.
Keywords: memory cells; hiv; specific memory; hiv specific ... See more keywords
Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy
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DOI: 10.1016/j.ebiom.2020.102727
Abstract: Background Untreated HIV infection leads to alterations in HIV-specific CD4+ T cells including increased expression of co-inhibitory receptors (IRs) and skewing toward a T follicular helper cell (Tfh) signature. However, which changes are maintained after… read more here.
Keywords: antiretroviral therapy; ctfh; hiv; th1 ... See more keywords
HIV-specific CD4+Th17 cells from HIV infected long-term non-progressors exhibit lower CTLA-4 expression and reduced apoptosis.
Sign Up to like & getrecommendations! Published in 2018 at "Immunobiology"
DOI: 10.1016/j.imbio.2018.07.011
Abstract: Progressive HIV infection is marked with reduced frequency and impaired function of Th17 cells. Since T-cell functional responses are regulated by various inhibitory receptors; we examined the expression profile of CTLA-4, PD-1, Tim-3 and apoptotic… read more here.
Keywords: ctla; th17 cells; expression; hiv specific ... See more keywords
Immunological function of Langerhans cells in HIV infection.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2017.03.015
Abstract: BACKGROUND Langerhans cells (LCs) are one of the initial target cells for HIV following sexual exposure and they are productively infected by HIV. HIV-infected LCs migrate to the draining lymph nodes (dLNs) and transmit the… read more here.
Keywords: specific cd8; cd8 cells; hiv; hiv primed ... See more keywords
DNA-MVA-protein vaccination of rhesus macaques induces HIV-specific immunity in mucosal-associated lymph nodes and functional antibodies
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DOI: 10.1016/j.vaccine.2016.12.060
Abstract: Successful future HIV vaccines are expected to generate an effective cellular and humoral response against the virus in both the peripheral blood and mucosal compartments. We previously reported the development of DNA-C and MVA-C vaccines… read more here.
Keywords: associated lymph; mucosal; mucosal associated; rhesus macaques ... See more keywords
HLA-G+ HIV-1-specific CD8+ T cells are associated with HIV-1 immune control
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DOI: 10.1097/qad.0000000000001326
Abstract: Objective(s): To assess the frequency and function of HIV-1-specific HLA-G+ (histocompatibility antigen class I, G) CD8+ T cells in HIV-1 controllers and progressors. Design: We performed an observational cross-sectional cohort analysis in untreated (n = 47) and… read more here.
Keywords: specific cd8; cd8 cells; hiv; hla ... See more keywords
Immune checkpoint inhibitors in people living with HIV: what about anti-HIV effects?
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DOI: 10.1097/qad.0000000000002397
Abstract: : Immune checkpoint inhibitors (ICPi) have shown major therapeutic successes when used in various cancers. In the HIV field a double benefit of such ICPi should result from their dual ability to restore in-vitro HIV-specific… read more here.
Keywords: specific cd8; hiv dna; immune checkpoint; hiv ... See more keywords
PD-1HI T cells are associated with lower hiv-specific immune responses despite long-term antiretroviral therapy.
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DOI: 10.1097/qad.0000000000002406
Abstract: OBJECTIVE We evaluated frequencies of T cells with high PD-1 expression (PD-1) before and after long-term effective antiretroviral therapy (ART), and determined if frequencies on-ART correlated positively with measures of HIV persistence and negatively with… read more here.
Keywords: hiv; long term; cell; hiv specific ... See more keywords
HIV Controllers Have Low Inflammation Associated with a Strong HIV-Specific Immune Response in Blood
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DOI: 10.1128/jvi.01690-18
Abstract: A small minority of HIV-infected patients, called HIV controllers (HIC), maintains spontaneous control of HIV replication. It is therefore important to identify mechanisms that contribute to the control of HIV replication that may have implications… read more here.
Keywords: blood; hiv; strong hiv; cell ... See more keywords
Contrasting Roles of the PD-1 Signaling Pathway in Dendritic Cell-Mediated Induction and Regulation of HIV-1-Specific Effector T Cell Functions
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DOI: 10.1128/jvi.02035-18
Abstract: Targeting the PD-1/PD-L1 immune checkpoint axis with signaling inhibitors has proven to be a powerful immunotherapeutic strategy to enhance the functional quality and survival of existing antigen-specific effector T cells. However, our study demonstrates that… read more here.
Keywords: cell; induction; signaling pathway; hiv specific ... See more keywords
Sustainable Antiviral Efficacy of Rejuvenated HIV-Specific Cytotoxic T Lymphocytes Generated from Induced Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.02217-21
Abstract: Elimination of latently HIV-infected cells is required for HIV cure. In the “kick and kill” strategy proposed for a cure to HIV, the host immune system, including HIV-specific cytotoxic T lymphocytes (CTLs), play a central… read more here.
Keywords: hiv specific; ipsc ctl; hiv; cure ... See more keywords