A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains
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DOI: 10.1128/mbio.00009-23
Abstract: With a small genome of ~9.2 kb that encodes 14 major proteins, HIV must hijack host cellular machinery to successfully establish infection. These host proteins necessary for HIV replication are called “dependency factors.” Whole-genome, and then… read more here.
Keywords: hiv strains; hiv; dependency factors; host ... See more keywords
Distinctive variation in the U3R region of the 5' Long Terminal Repeat from diverse HIV-1 strains
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DOI: 10.1371/journal.pone.0195661
Abstract: Functional mapping of the 5’LTR has shown that the U3 and the R regions (U3R) contain a cluster of regulatory elements involved in the control of HIV-1 transcription and expression. As the HIV-1 genome is… read more here.
Keywords: hiv strains; crf22 01a1; hiv; diverse hiv ... See more keywords