Differential Mechanisms of Inflammation and Endothelial Dysfunction by HIV-1 Subtype-B and Recombinant CRF02_AG Tat Proteins on Human Brain Microvascular Endothelial Cells: Implications for Viral Neuropathogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0382-0
Abstract: The recombinant HIV-1 CRF02_AG is prevalent in West-Central Africa but its effects on the blood-brain barrier (BBB) and HIV-associated neurocognitive disorders (HAND) are not known. We analyzed the effects of Tat from HIV-1 subtype-B (Tat.B)… read more here.
Keywords: hiv; hiv subtype; brain; tat ... See more keywords
Development of a pseudovirus assay and evaluation to screen natural products for inhibition of HIV-1 subtype C reverse transcriptase.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.112931
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Medicinal plants are used in the management of Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome (HIV/AIDS) in many developing country settings where HIV-1 subtype C drives the epidemic. Efforts to identify plant derived… read more here.
Keywords: plant; pseudovirus assay; hiv; inhibition ... See more keywords
Human leukocyte antigen-associated gag and nef polymorphisms in HIV-1 subtype A/E-infected individuals in Vietnam.
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DOI: 10.1016/j.micinf.2018.10.001
Abstract: Numbers of HLA-associated polymorphisms have been reported on HIV-1 subtypes B and C, but few on other subtypes. Here, we analyzed HLA-associated gag and nef polymorphisms in HIV-1 subtype A/E prevalent in Vietnam. We determined… read more here.
Keywords: polymorphisms hiv; gag nef; associated gag; hiv subtype ... See more keywords
Signatures of HIV-1 subtype B and C Tat proteins and their effects in the neuropathogenesis of HIV-associated neurocognitive impairments
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DOI: 10.1016/j.nbd.2019.104701
Abstract: HIV-associated neurocognitive impairments (HANI) are a spectrum of neurological disorders due to the effects of HIV-1 on the central nervous system (CNS). The HIV-1 subtypes; HIV-1 subtype B (HIV-1B) and HIV-1 subtype C (HIV-1C) are… read more here.
Keywords: hiv; hiv subtype; associated neurocognitive; tat ... See more keywords
Envelope characteristics in individuals who developed neutralizing antibodies targeting different epitopes in HIV-1 subtype C infection.
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DOI: 10.1016/j.virol.2020.03.003
Abstract: Broadly neutralizing antibodies (bNAbs) may constitute an essential component of a protective vaccine against HIV-1, yet no immunogen has been able to elicit them. To characterize the development of bNAbs in HIV-1 subtype C infected… read more here.
Keywords: individuals developed; neutralizing antibodies; hiv subtype; subtype infection ... See more keywords
Molecular Epidemiology of HIV-1 Virus in Puerto Rico: Novel Cases of HIV-1 Subtype C, D, and CRF-24BG.
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DOI: 10.1089/aid.2017.0305
Abstract: HIV-1 subtype B virus is the most prevalent subtype in Puerto Rico (PR), accounting for about 90% of infection in the island. Recently, other subtypes and circulating recombinant forms (CRFs), including F(12_BF), A (01_BF), and… read more here.
Keywords: crf 24bg; hiv; hiv subtype; epidemiology ... See more keywords
Characterization of Four Nearly Full-Length Genomic Sequences of HIV-1 Subtype G Identified in Guangdong Province, China.
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DOI: 10.1089/aid.2019.0025
Abstract: Four cases infected by HIV-1 subtype G strain were identified in Guangdong, China. The nearly full-length genome was amplified and sequenced for phylogenetic analysis. The four sequences clustered together with subtype G references in the… read more here.
Keywords: full length; identified guangdong; nearly full; china ... See more keywords
New antiretroviral inhibitors and HIV-1 drug resistance: more focus on 90% HIV-1 isolates?
Sign Up to like & getrecommendations! Published in 2022 at "FEMS microbiology reviews"
DOI: 10.1093/femsre/fuac040
Abstract: Combined HIV antiretroviral therapy (cART) has been effective except if drug resistance emerges. As cART has been rolled out in low-income countries, drug resistance has emerged at higher rates than observed in high income countries… read more here.
Keywords: hiv subtype; resistance; income countries; drug ... See more keywords
Control of HIV-1 Replication by CD8+ T Cells Specific for Two Novel Pol Protective Epitopes in HIV-1 Subtype A/E Infection
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DOI: 10.1128/jvi.00811-22
Abstract: It is expected that HIV-1-specific CD8+ T cells that effectively suppress HIV-1 replication will contribute to HIV-1 vaccine development and therapy to achieve an HIV cure. T cells specific for protective epitopes were identified in… read more here.
Keywords: hiv replication; hiv subtype; hiv; subtype infection ... See more keywords
Expanding HIV-1 subtype B transmission networks among men who have sex with men in Poland
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DOI: 10.1371/journal.pone.0172473
Abstract: Introduction Reconstruction of HIV transmission links allows to trace the spread and dynamics of infection and guide epidemiological interventions. The aim of this study was to characterize transmission networks among subtype B infected patients from… read more here.
Keywords: transmission; hiv; networks among; transmission networks ... See more keywords
Prediction of coreceptor usage by five bioinformatics tools in a large Ethiopian HIV-1 subtype C cohort
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DOI: 10.1371/journal.pone.0182384
Abstract: Background Genotypic tropism testing (GTT) has been developed largely on HIV-1 subtype B. Although a few reports have analysed the utility of GTT in other subtypes, more studies using HIV-1 subtype C (HIV-1C) are needed,… read more here.
Keywords: hiv subtype; hiv; coreceptor usage; tropism ... See more keywords