Conditional expression of HIV-1 Tat in the mouse alters the onset and progression of tonic, inflammatory, and neuropathic hypersensitivity in a sex-dependent manner.
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DOI: 10.1002/ejp.1618
Abstract: At least one third of HIV-1-afflicted individuals experience peripheral neuropathy. Although the underlying mechanisms are not known, they may involve neurotoxic HIV-1 proteins. We assessed the influence of the neurotoxic HIV-1 regulatory protein, Tat, on… read more here.
Keywords: hiv; sex; hiv tat; hypersensitivity ... See more keywords
Novel insights into role of miR‐320a‐VDAC1 axis in astrocyte‐mediated neuronal damage in neuroAIDS
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DOI: 10.1002/glia.23089
Abstract: Astroglia are indispensable component of the tripartite synapse ensheathing innumerous soma and synapses. Its proximity to neurons aids the regulation of neuronal functions, health and survival through dynamic neuroglia crosstalk. Susceptibility of astrocyte to HIV‐1… read more here.
Keywords: hiv; vdac1; hiv tat; atp release ... See more keywords
Rho-kinase inhibitor hydroxyfasudil protects against HIV-1 Tat-induced dysfunction of tight junction and neprilysin/Aβ transfer receptor expression in mouse brain microvessels
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DOI: 10.1007/s11010-021-04056-x
Abstract: HIV-1 transactivator protein (Tat) induces tight junction (TJ) dysfunction and amyloid-beta (Aβ) clearance dysfunction, contributing to the development and progression of HIV-1-associated neurocognitive disorder (HAND). The Rho/ROCK signaling pathway has protective effects on neurodegenerative disease.… read more here.
Keywords: mouse brain; dysfunction; hiv tat; receptor ... See more keywords
HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture
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DOI: 10.1007/s11481-019-09869-8
Abstract: Although combination antiretroviral therapy (cART) has improved the health of millions of those living with HIV-1 (Human Immunodeficiency Virus, Type 1), the penetration into the central nervous system (CNS) of many such therapies is limited,… read more here.
Keywords: extracellular vesicle; mir; hiv; hiv tat ... See more keywords
Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of NeuroVirology"
DOI: 10.1007/s13365-017-0598-9
Abstract: HIV-1 Tat is known to be neurotoxic and important for HIV/neuroAIDS pathogenesis. However, the overwhelming majority of the studies involved use of recombinant Tat protein. To understand the contributions of Tat protein to HIV/neuroAIDS and… read more here.
Keywords: astrocyte; hiv; hiv neuroaids; mice ... See more keywords
HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood–brain barrier integrity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of NeuroVirology"
DOI: 10.1007/s13365-019-00757-8
Abstract: Poor antiretroviral penetration may contribute to human immunodeficiency virus (HIV) persistence within the brain and to neurocognitive deficits in opiate abusers. To investigate this problem, HIV-1 Tat protein and morphine effects on blood–brain barrier (BBB)… read more here.
Keywords: blood brain; morphine; hiv tat; brain ... See more keywords
HIV-1C and HIV-1B Tat protein polymorphism in Southern Brazil.
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DOI: 10.1007/s13365-020-00935-z
Abstract: The transactivator of transcription (Tat) is a key HIV regulatory protein. We aimed to identify the frequency of key polymorphisms in HIV-1C compared with HIV-1B Tat protein, chiefly in the cysteine-, arginine-, and glutamine-rich domains… read more here.
Keywords: hiv; southern brazil; hiv hiv; hiv tat ... See more keywords
HIV-1 Tat protein attenuates the clinical course of experimental autoimmune encephalomyelitis (EAE).
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105943
Abstract: A growing body of evidence has shown that the human immunodeficiency virus (HIV) infection is associated with a significantly decreased risk of developing multiple sclerosis (MS) in patients with acquired immunodeficiency virus (AIDS). It is… read more here.
Keywords: protein; eae; mice; hiv tat ... See more keywords
HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2016.12.073
Abstract: HIV-1 infection results in blood-brain barrier (BBB) disruption, which acts as a rate-limiting step for HIV-1 entry into the CNS and for subsequent neuroinflammatory/neurotoxic actions. One mechanism by which HIV may destabilize the BBB involves… read more here.
Keywords: phagocytic perivascular; macrophages microglia; hiv tat; perivascular macrophages ... See more keywords
Morphine and HIV-1 Tat interact to cause region-specific hyperphosphorylation of tau in transgenic mice
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DOI: 10.1016/j.neulet.2020.135502
Abstract: Opiate abuse is prevalent among HIV-infected individuals and may exacerbate HIV-associated age-related neurocognitive disorders. However, the extent to which HIV and opiates converge to accelerate pathological traits indicative of brain aging remains unknown. The pathological… read more here.
Keywords: tau; morphine; mice; hiv tat ... See more keywords
Combined HIV-1 Tat and oxycodone activate the hypothalamic-pituitary-adrenal and -gonadal axes and promote psychomotor, affective, and cognitive dysfunction in female mice
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DOI: 10.1016/j.yhbeh.2019.104649
Abstract: The majority of HIV+ patients present with neuroendocrine dysfunction and ~50% experience co-morbid neurological symptoms including motor, affective, and cognitive dysfunction, collectively termed neuroHIV. In preclinical models, the neurotoxic HIV-1 regulatory protein, trans-activator of transcription… read more here.
Keywords: dysfunction; pathology; mice; hiv tat ... See more keywords