Finding host targets for HIV therapy
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3777
Abstract: A CRISPR screen conducted in a CD4+ T cell leukemia line has identified host factors required for HIV infection but dispensable for cellular survival. The results highlight sulfation on the HIV co-receptor CCR5 and cellular… read more here.
Keywords: host targets; targets hiv; finding host; hiv therapy ... See more keywords
Application of CRISPR/Cas Genomic Editing Tools for HIV Therapy: Toward Precise Modifications and Multilevel Protection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.880030
Abstract: Although highly active antiretroviral therapy (HAART) can robustly control human immunodeficiency virus (HIV) infection, the existence of latent HIV in a form of proviral DNA integrated into the host genome makes the virus insensitive to… read more here.
Keywords: hiv therapy; crispr cas; editing; hiv ... See more keywords
Pharmacogenetic Markers: A Path toward Individualized HIV Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "MEDICC review"
DOI: 10.37757/mr2019.v21.n2-3.11
Abstract: INTRODUCTION Approximately 73% of persons with HIV who receive antiretroviral therapy in Cuba are in viral suppression. The non-response of the remaining 27% could be due to several factors including adverse drug reactions and HIV… read more here.
Keywords: antiretroviral therapy; hiv therapy; drug; antiretroviral drugs ... See more keywords