The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA Pol II from Binding to HIV-1 LTR.
Sign Up to like & getrecommendations! Published in 2021 at "Virologica Sinica"
DOI: 10.1007/s12250-021-00363-1
Abstract: The CREB-regulated transcriptional co-activators (CRTCs), including CRTC1, CRTC2 and CRTC3, enhance transcription of CREB-targeted genes. In addition to regulating host gene expression in response to cAMP, CRTCs also increase the infection of several viruses. While… read more here.
Keywords: transcription; hiv; infection; hiv transcription ... See more keywords
HIV Transcription is Independent of Mediator Kinases.
Sign Up to like & getrecommendations! Published in 2019 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2019.0039
Abstract: While the roles in HIV transcription of many cyclin-dependent kinases (CDKs) have been well defined, little is known about the impact of mediator kinases (MDKs), CDK8 and CDK19, in this process. Mediator complexes containing CDK8… read more here.
Keywords: mediator kinases; independent mediator; hiv transcription; transcription ... See more keywords
Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals
Sign Up to like & getrecommendations! Published in 2019 at "AIDS"
DOI: 10.1097/qad.0000000000002083
Abstract: Objectives: Reversing HIV-1 latency has been suggested as a strategy to eradicate HIV-1. We investigated the effect of romidepsin on the HIV transcription profile in participants from the REDUC part B clinical trial. Design: Seventeen… read more here.
Keywords: romidepsin; hiv; hiv transcription; transcription profile ... See more keywords
Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/6055347
Abstract: The principal barrier for the eradication of HIV/AIDS is the virus latency. One of the effective strategies so called “shock and kill” is to use latency-reversing agents (LRAs) to activate the latent HIV reservoirs and… read more here.
Keywords: reactivate latent; latent hiv; hiv; hiv transcription ... See more keywords
Immune regulator ABIN1 suppresses HIV-1 transcription by negatively regulating the ubiquitination of Tat
Sign Up to like & getrecommendations! Published in 2017 at "Retrovirology"
DOI: 10.1186/s12977-017-0338-5
Abstract: BackgroundA20-binding inhibitor of NF-κB activation (ABIN1), an important immune regulator, was previously shown to be involved in HIV-1 replication. However, the reported studies done with overexpressed ABIN1 provided controversial results.ResultsHere we identified ABIN1 as a… read more here.
Keywords: transcription; hiv transcription; abin1; immune regulator ... See more keywords
DDX5 potentiates HIV-1 transcription as a co-factor of Tat
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DOI: 10.1186/s12977-020-00514-4
Abstract: Background HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was… read more here.
Keywords: factor; tat; ddx5; hiv transcription ... See more keywords
Identification of benzazole compounds that induce HIV-1 transcription
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0179100
Abstract: Despite advances in antiretroviral therapy, HIV-1 infection remains incurable in patients and continues to present a significant public health burden worldwide. While a number of factors contribute to persistent HIV-1 infection in patients, the presence… read more here.
Keywords: benzazole compounds; compounds induce; hiv transcription; benzazole ... See more keywords
Protein Phosphatase-1 -targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals.
Sign Up to like & getrecommendations! Published in 2017 at "Current pharmaceutical design"
DOI: 10.2174/1381612823666170704123620
Abstract: BACKGROUND Despite efficient suppression of HIV-1 replication, current antiviral drugs are not able to eradicate HIV-1 infection. Permanent HIV-1 suppression or complete eradication requires novel biological approaches and therapeutic strategies. Our previous studies showed that… read more here.
Keywords: curcumin analogs; phosphatase; small molecules; hiv transcription ... See more keywords
Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling
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DOI: 10.3389/fimmu.2019.00267
Abstract: Endogenous plasma levels of the immunomodulatory carbohydrate-binding protein galectin-9 (Gal-9) are elevated during HIV infection and remain elevated after antiretroviral therapy (ART) suppression. We recently reported that Gal-9 regulates HIV transcription and potently reactivates latent… read more here.
Keywords: latency; gal; hiv transcription; reactivation ... See more keywords
HIV-1 Transcription Inhibitor 1E7-03 Restores LPS-Induced Alteration of Lung Leukocytes’ Infiltration Dynamics and Resolves Inflammation in HIV Transgenic Mice
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12020204
Abstract: Human immunodeficiency virus (HIV)-infected individuals treated with anti-retroviral therapy often develop chronic non-infectious lung disease. To determine the mechanism of HIV-1-associated lung disease we evaluated the dynamics of lung leukocytes in HIV-1 transgenic (Tg) mice… read more here.
Keywords: infiltration; hiv; hiv transcription; mice ... See more keywords