A qualitative study of stakeholder and researcher perspectives of community engagement practices for HIV vaccine clinical trials in South Africa.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of community psychology"
DOI: 10.1002/jcop.22951
Abstract: Community engagement increases community trust of research and improves trial participation. However, there is limited documented appraisal of community engagement practices. Several HIV vaccine efficacy trials have been conducted in South Africa, the country most… read more here.
Keywords: community engagement; engagement practices; community; hiv vaccine ... See more keywords
The path to find an HIV vaccine
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25749
Abstract: Since the discovery that a retrovirus, human immunodeficiency virus type one (HIV-1), causes the acquired immune deficiency syndrome (AIDS), more than 77 million people have become infected with HIV and 37 million have died over… read more here.
Keywords: hiv; antibody; efficacy; neutralizing antibodies ... See more keywords
Current approaches to HIV vaccine development: a narrative review
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DOI: 10.1002/jia2.25793
Abstract: The development of an effective vaccine to protect against HIV is a longstanding global health need complicated by challenges inherent to HIV biology and to the execution of vaccine efficacy testing in the context of… read more here.
Keywords: vaccine development; vaccine; approaches hiv; hiv vaccine ... See more keywords
A transformed global enterprise for an HIV vaccine
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DOI: 10.1002/jia2.25822
Abstract: First stakeholders meeting held at the Wellcome Trust in London, UK, followed by a Funder's forum. European AIDS Vaccine Initiative (EAVI2020) and the European HIV Vaccine Alliance (EHVA) are funded by the European Commission to… read more here.
Keywords: global enterprise; hiv; transformed global; vaccine ... See more keywords
Iterative hypothesis testing in HIV vaccine research: moving towards success
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DOI: 10.1002/jia2.26102
Abstract: The development of an HIV vaccine remains a critical goal for global health. New and emerging prevention methods, such as long-acting pre-exposure prophylaxis, may help reduce the risk of HIV acquisition, but it is widely… read more here.
Keywords: hiv; infection; hiv vaccine; vaccine ... See more keywords
Achieving intracellular cytokine staining assay concordance on two continents to assess HIV vaccine‐induced T‐cell responses
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5ma0522-668r
Abstract: The HIV Vaccine Trials Network (HVTN) conducts clinical trials on 4 continents in pursuit of a safe and effective HIV vaccine. Cellular immune responses to vaccination that define vaccine immunogenicity and/or immune correlates of protection… read more here.
Keywords: cell; concordance; intracellular cytokine; hiv vaccine ... See more keywords
Maximum diversity weighting for biomarkers with application in HIV-1 vaccine studies.
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DOI: 10.1002/sim.8212
Abstract: While studying the association between risk of HIV-1 infection and vaccine-elicited immune responses in preventative HIV-1 vaccine recipients, we encountered a need to combine a collection of biomarkers in an unsupervised fashion with the goal… read more here.
Keywords: diversity; maximum diversity; diversity weighting; weighting biomarkers ... See more keywords
Fundamental challenges to the development of a preventive HIV vaccine.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2018.02.004
Abstract: There is consensus that only a preventive vaccine can contain the HIV/AIDS pandemic. After 30 years still there is no preventive HIV vaccine. This article examines fundamental challenges to the development of a preventive HIV… read more here.
Keywords: fundamental challenges; hiv; challenges development; vaccine ... See more keywords
The repeated setbacks of HIV vaccine development laid the groundwork for SARS-CoV-2 vaccines
Sign Up to like & getrecommendations! Published in 2022 at "Health Policy and Technology"
DOI: 10.1016/j.hlpt.2022.100619
Abstract: The decades-long effort to produce a workable HIV vaccine has hardly been a waste of public and private resources. To the contrary, the scientific know-how acquired along the way has served as the critical foundation… read more here.
Keywords: hiv vaccine; sars cov; cov vaccines; vaccine ... See more keywords
Exploring evidence for behavioral risk compensation among participants in an HIV vaccine clinical trial.
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DOI: 10.1016/j.vaccine.2017.05.024
Abstract: BACKGROUND HIV vaccine trial participants may engage in behavioral risk compensation due to a false sense of protection. We conducted an ancillary study of an HIV Vaccine Trials Network (HVTN) vaccine efficacy trial to explore… read more here.
Keywords: trial participants; trial; vaccine trial; risk compensation ... See more keywords
Lessons for general vaccinology research from attempts to develop an HIV vaccine.
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DOI: 10.1016/j.vaccine.2019.04.005
Abstract: In the past when large investments have been made in tackling narrow scientific challenges, the enormous expansion in our knowledge in one small area has had a spill-over effect on research and treatment of other… read more here.
Keywords: research; vaccine lessons; vaccine; hiv vaccine ... See more keywords