The Role of RNA in HIV-1 Vif-Mediated Degradation of APOBEC3H.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.09.014
Abstract: As many as five members of the APOBEC3 family of DNA cytosine deaminases are capable of inhibiting HIV-1 replication by deaminating viral cDNA cytosines and interfering with reverse transcription. HIV-1 counteracts restriction with the virally… read more here.
Keywords: degradation apobec3h; hiv; rna; hiv vif ... See more keywords
Demystifying Cell Cycle Arrest by HIV-1 Vif.
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DOI: 10.1016/j.tim.2021.01.001
Abstract: Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that… read more here.
Keywords: cycle arrest; cell; cell cycle; hiv vif ... See more keywords
Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.00631-20
Abstract: A critical function of HIV-1 Vif is to counteract the family of APOBEC3 innate immune proteins. It is also widely accepted that Vif induces G2/M cell cycle arrest in several different cell types. Recently, it… read more here.
Keywords: vif; hiv; hiv vif; degradation ... See more keywords